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- W3027281582 startingPage "1312" @default.
- W3027281582 abstract "Recent advances in genome engineering based on the CRISPR/Cas9 technology have revolutionized our ability to manipulate genomic DNA. Its use in human pluripotent stem cells (hPSCs) has allowed a wide range of mutant cell lines to be obtained at an unprecedented rate. The combination of these two groundbreaking technologies has tremendous potential, from disease modeling to stem cell-based therapies. However, the generation, screening and molecular characterization of these cell lines remain a cumbersome and multi-step endeavor. Here, we propose a pipeline of strategies to efficiently generate, sub-clone, and characterize CRISPR/Cas9-edited hPSC lines in the function of the introduced mutation (indels, point mutations, insertion of large constructs, deletions)." @default.
- W3027281582 created "2020-05-29" @default.
- W3027281582 creator A5031503223 @default.
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- W3027281582 date "2020-05-25" @default.
- W3027281582 modified "2023-09-25" @default.
- W3027281582 title "Pipeline for the Generation and Characterization of Transgenic Human Pluripotent Stem Cells Using the CRISPR/Cas9 Technology" @default.
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- W3027281582 doi "https://doi.org/10.3390/cells9051312" @default.
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