FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027298771> ?p ?o ?g. }

• W3027298771 endingPage "173200" @default.
• W3027298771 startingPage "173200" @default.
• W3027298771 abstract "Nutritional imbalance in early life may disrupt the hypothalamic control of energy homeostasis and increase the risk of metabolic disease. The hypothalamic serotonin (5-hydroxytryptamine; 5-HT) system based in the hypothalamus plays an important role in the homeostatic control of energy balance, however the mechanisms underlying the regulation of energy metabolism by 5-HT remain poorly described. Several crucial mitochondrial functions are altered by mitochondrial stress. Adaptations to this stress include changes in mitochondrial multiplication (i.e, mitochondrial biogenesis). Due to the scarcity of evidence regarding the effects of serotonin reuptake inhibitors (SSRI) such as fluoxetine (FLX) on mitochondrial function, we sought to investigate the potential contribution of FLX on changes in mitochondrial function and biogenesis occurring in overfed rats. Using a neonatal overfeeding model, male Wistar rats were divided into 4 groups between 39 and 59 days of age based on nutrition and FLX administration: normofed + vehicle (NV), normofed + FLX (NF), overfed + vehicle (OV) and overfed + FLX (OF). We found that neonatal overfeeding impaired mitochondrial respiration and increased oxidative stress biomarkers in the hypothalamus. FLX administration in overfed rats reestablished mitochondrial oxygen consumption, increased mitochondrial uncoupling protein 2 (Ucp2) expression, reduced total reactive species (RS) production and oxidative stress biomarkers, and up-regulated mitochondrial biogenesis-related genes. Taken together our results suggest that FLX administration in overfed rats improves mitochondrial respiratory chain activity and oxidative balance and increases the transcription of genes employed in mitochondrial biogenesis favoring mitochondrial energy efficiency in response to early nutritional imbalance." @default.
• W3027298771 created "2020-05-29" @default.
• W3027298771 creator A5022234862 @default.
• W3027298771 creator A5030052398 @default.
• W3027298771 creator A5039981861 @default.
• W3027298771 creator A5043413018 @default.
• W3027298771 creator A5082834316 @default.
• W3027298771 creator A5087649408 @default.
• W3027298771 creator A5026124623 @default.
• W3027298771 date "2020-08-01" @default.
• W3027298771 modified "2023-10-16" @default.
• W3027298771 title "Fluoxetine administration in juvenile overfed rats improves hypothalamic mitochondrial respiration and REDOX status and induces mitochondrial biogenesis transcriptional expression" @default.
• W3027298771 cites W1567614586 @default.
• W3027298771 cites W1590457525 @default.
• W3027298771 cites W1693408209 @default.
• W3027298771 cites W179761311 @default.
• W3027298771 cites W1973346625 @default.
• W3027298771 cites W1979017842 @default.
• W3027298771 cites W1982104904 @default.
• W3027298771 cites W1996652459 @default.
• W3027298771 cites W1998578765 @default.
• W3027298771 cites W2003342987 @default.
• W3027298771 cites W2007649442 @default.
• W3027298771 cites W2026261400 @default.
• W3027298771 cites W2026342628 @default.
• W3027298771 cites W2051038490 @default.
• W3027298771 cites W2062875259 @default.
• W3027298771 cites W2063057450 @default.
• W3027298771 cites W2063738240 @default.
• W3027298771 cites W2069767145 @default.
• W3027298771 cites W2073703119 @default.
• W3027298771 cites W2074195231 @default.
• W3027298771 cites W2102881113 @default.
• W3027298771 cites W2107277218 @default.
• W3027298771 cites W2112809623 @default.
• W3027298771 cites W2125448028 @default.
• W3027298771 cites W2126337135 @default.
• W3027298771 cites W2138880415 @default.
• W3027298771 cites W2152165298 @default.
• W3027298771 cites W2154696002 @default.
• W3027298771 cites W2160294830 @default.
• W3027298771 cites W2209035063 @default.
• W3027298771 cites W2313583633 @default.
• W3027298771 cites W2347041376 @default.
• W3027298771 cites W256530927 @default.
• W3027298771 cites W2590195408 @default.
• W3027298771 cites W2593961493 @default.
• W3027298771 cites W2610426560 @default.
• W3027298771 cites W2737422549 @default.
• W3027298771 cites W2741958826 @default.
• W3027298771 cites W2766580848 @default.
• W3027298771 cites W2789540632 @default.
• W3027298771 cites W2792568355 @default.
• W3027298771 cites W2803894908 @default.
• W3027298771 cites W2808686421 @default.
• W3027298771 cites W2887672658 @default.
• W3027298771 cites W2905573083 @default.
• W3027298771 cites W2999576554 @default.
• W3027298771 cites W4293247451 @default.
• W3027298771 cites W4294216491 @default.
• W3027298771 doi "https://doi.org/10.1016/j.ejphar.2020.173200" @default.
• W3027298771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32445706" @default.
• W3027298771 hasPublicationYear "2020" @default.
• W3027298771 type Work @default.
• W3027298771 sameAs 3027298771 @default.
• W3027298771 citedByCount "6" @default.
• W3027298771 countsByYear W30272987712021 @default.
• W3027298771 countsByYear W30272987712022 @default.
• W3027298771 countsByYear W30272987712023 @default.
• W3027298771 crossrefType "journal-article" @default.
• W3027298771 hasAuthorship W3027298771A5022234862 @default.
• W3027298771 hasAuthorship W3027298771A5026124623 @default.
• W3027298771 hasAuthorship W3027298771A5030052398 @default.
• W3027298771 hasAuthorship W3027298771A5039981861 @default.
• W3027298771 hasAuthorship W3027298771A5043413018 @default.
• W3027298771 hasAuthorship W3027298771A5082834316 @default.
• W3027298771 hasAuthorship W3027298771A5087649408 @default.
• W3027298771 hasBestOaLocation W30272987711 @default.
• W3027298771 hasConcept C126322002 @default.
• W3027298771 hasConcept C134018914 @default.
• W3027298771 hasConcept C2491326 @default.
• W3027298771 hasConcept C2776151105 @default.
• W3027298771 hasConcept C2777229759 @default.
• W3027298771 hasConcept C2779177272 @default.
• W3027298771 hasConcept C2780092697 @default.
• W3027298771 hasConcept C2781161787 @default.
• W3027298771 hasConcept C28859421 @default.
• W3027298771 hasConcept C3020377403 @default.
• W3027298771 hasConcept C3020761558 @default.
• W3027298771 hasConcept C511355011 @default.
• W3027298771 hasConcept C71924100 @default.
• W3027298771 hasConcept C86803240 @default.
• W3027298771 hasConcept C95444343 @default.
• W3027298771 hasConceptScore W3027298771C126322002 @default.
• W3027298771 hasConceptScore W3027298771C134018914 @default.
• W3027298771 hasConceptScore W3027298771C2491326 @default.
• W3027298771 hasConceptScore W3027298771C2776151105 @default.
• W3027298771 hasConceptScore W3027298771C2777229759 @default.

• next