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• W3027365662 abstract "Abstract Background Compulsivity and loss of behavioral control represent core symptoms in obsessive-compulsive disorder (OCD), substance use disorder (SUD), and internet gaming disorder (IGD). Despite animal models suggesting compulsivity mediated by cortico-striatal circuits and several neuroimaging case-control studies positing common/distinct neurofunctional alterations in these disorders a systematic examination is still lacking. Aims The present study capitalized on previous case-control fMRI studies to determine shared and disorder-specific neurofunctional alterations among three disorders. Methods Task-based fMRI studies in SUD, OCD, and IGD were obtained. Coordinate-based meta-analyses were performed within each disorder. Next contrast and conjunction meta-analyses were done to determine differential and common neurofunctional alterations between the disorders. Task-paradigm were group according to RDoC domains to determine contributions of underlying behavioral domains. Find pre-registration of the study here ( https://osf.io/j8wct/ ). Results 144 articles were included representing 6897 individuals (SUD=2418, controls=2332; IGD=361, controls=360; OCD=715, controls=711). Conjunction meta-analyses revealed shared alterations in anterior insular cortex between OCD, and pooled as-well-as separate SUDs. SUD exhibited pronounced dorso-striatal alterations as compared to both, OCD and IGD. IGD shared frontal, particularly cingulate alterations with all SUDs. IGD demonstrated temporal alterations compared to both, SUD and OCD. No robust overlap between IGD and OCD was observed. Across the disorders, neurofunctional alterations were mainly contributed to by cognitive systems and positive valence RDoC domains. Conclusion The present findings indicate that neurofunctional dysregulations in prefrontal regions engaged in regulatory control share neurofunctional alterations across substance and behavioral addictions, while shared neurofunctional dysregulations in the anterior insula may mediate compulsivity in substance addiction and obsessive-compulsive disorders." @default.
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• W3027365662 date "2020-05-26" @default.
• W3027365662 modified "2023-10-18" @default.
• W3027365662 title "Common and separable neurofunctional dysregulations characterize obsessive-compulsive, substance use, and gaming disorders – evidence from an activation likelihood meta-analysis of functional imaging studies" @default.
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• W3027365662 doi "https://doi.org/10.1101/2020.05.21.20108316" @default.
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