FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027366955> ?p ?o ?g. }

• W3027366955 endingPage "e1003104" @default.
• W3027366955 startingPage "e1003104" @default.
• W3027366955 abstract "Background The relation between prepregnancy average glucose concentration and a woman’s risk of severe maternal morbidity (SMM) is unknown. The current study evaluated whether an elevated preconception hemoglobin A1c (A1c) is associated with SMM or maternal death among women with and without known prepregnancy diabetes mellitus (DM). Methods and findings A population-based cohort study was completed in Ontario, Canada, where there is universal healthcare. The main cohort included 31,225 women aged 16–50 years with a hospital live birth or stillbirth from 2007 to 2015, and who had an A1c measured within 90 days before conception, including 28,075 women (90%) without known prepregnancy DM. The main outcome was SMM or maternal mortality from 23 weeks’ gestation up to 42 days postpartum. Relative risks (RRs) were generated using modified Poisson regression, adjusting for the main covariates of maternal age, multifetal pregnancy, world region of origin, and tobacco/drug dependence. The mean maternal age was 31.1 years. Overall, SMM or death arose among 682 births (2.2%). The RR of SMM or death was 1.16 (95% CI 1.14–1.19; p < 0.001) per 0.5% increase in A1c and 1.16 (95% CI 1.13–1.18; p < 0.001) after adjusting for the main covariates. The adjusted relative risk (aRR) was increased among those with (1.11, 95% CI 1.07–1.14; p < 0.001) and without (1.15, 95% CI 1.02–1.29; p < 0.001) known prepregnancy diabetes, and upon further adjusting for body mass index (BMI) (1.15, 95% CI 1.11–1.20; p < 0.001), or chronic hypertension and prepregnancy serum creatinine (1.11, 95% CI 1.04–1.18; p = 0.002). The aRR of SMM or death was 1.31 (95% CI 1.06–1.62; p = 0.01) in those with a preconception A1c of 5.8%–6.4%, and 2.84 (95% CI 2.31–3.49; p < 0.001) at an A1c > 6.4%, each relative to an A1c < 5.8%. Among those without previously recognized prepregnancy diabetes and whose A1c was >6.4%, the aRR of SMM or death was 3.25 (95% CI 1.76–6.00; p < 0.001). Study limitations include that selection bias may have incorporated less healthy women tested for A1c, and BMI was unknown for many women. Conclusions Our findings indicate that women with an elevated A1c preconception may be at higher risk of SMM or death in pregnancy or postpartum, including those without known prepregnancy DM." @default.
• W3027366955 created "2020-05-29" @default.
• W3027366955 creator A5001067933 @default.
• W3027366955 creator A5012569105 @default.
• W3027366955 creator A5026310393 @default.
• W3027366955 creator A5056937094 @default.
• W3027366955 creator A5059975383 @default.
• W3027366955 creator A5089324678 @default.
• W3027366955 creator A5089782295 @default.
• W3027366955 date "2020-05-19" @default.
• W3027366955 modified "2023-10-16" @default.
• W3027366955 title "Risk of severe maternal morbidity or death in relation to elevated hemoglobin A1c preconception, and in early pregnancy: A population-based cohort study" @default.
• W3027366955 cites W1492385092 @default.
• W3027366955 cites W1550818700 @default.
• W3027366955 cites W1970777186 @default.
• W3027366955 cites W1976201033 @default.
• W3027366955 cites W1979187096 @default.
• W3027366955 cites W1984970610 @default.
• W3027366955 cites W2012944069 @default.
• W3027366955 cites W2015018495 @default.
• W3027366955 cites W2051211149 @default.
• W3027366955 cites W2052960582 @default.
• W3027366955 cites W2053488499 @default.
• W3027366955 cites W2059743234 @default.
• W3027366955 cites W2072461288 @default.
• W3027366955 cites W2098834507 @default.
• W3027366955 cites W2104967789 @default.
• W3027366955 cites W2108986141 @default.
• W3027366955 cites W2126381731 @default.
• W3027366955 cites W2137837290 @default.
• W3027366955 cites W2145125317 @default.
• W3027366955 cites W2145688382 @default.
• W3027366955 cites W2147325532 @default.
• W3027366955 cites W2151421940 @default.
• W3027366955 cites W2166000404 @default.
• W3027366955 cites W2218939947 @default.
• W3027366955 cites W2229680568 @default.
• W3027366955 cites W2320859418 @default.
• W3027366955 cites W2340668831 @default.
• W3027366955 cites W2469696781 @default.
• W3027366955 cites W2548368175 @default.
• W3027366955 cites W2577350081 @default.
• W3027366955 cites W2604193169 @default.
• W3027366955 cites W2769427421 @default.
• W3027366955 cites W2790823829 @default.
• W3027366955 cites W2792178736 @default.
• W3027366955 cites W2795370579 @default.
• W3027366955 cites W2800419398 @default.
• W3027366955 cites W2809225164 @default.
• W3027366955 cites W2883862550 @default.
• W3027366955 cites W2899667430 @default.
• W3027366955 cites W2903178948 @default.
• W3027366955 cites W2906002119 @default.
• W3027366955 cites W2908541000 @default.
• W3027366955 cites W2938524210 @default.
• W3027366955 cites W2943402728 @default.
• W3027366955 cites W2968579279 @default.
• W3027366955 cites W4211126177 @default.
• W3027366955 cites W4233931937 @default.
• W3027366955 cites W4251820864 @default.
• W3027366955 cites W4252245568 @default.
• W3027366955 cites W4292605750 @default.
• W3027366955 doi "https://doi.org/10.1371/journal.pmed.1003104" @default.
• W3027366955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7236974" @default.
• W3027366955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32427997" @default.
• W3027366955 hasPublicationYear "2020" @default.
• W3027366955 type Work @default.
• W3027366955 sameAs 3027366955 @default.
• W3027366955 citedByCount "24" @default.
• W3027366955 countsByYear W30273669552020 @default.
• W3027366955 countsByYear W30273669552022 @default.
• W3027366955 countsByYear W30273669552023 @default.
• W3027366955 crossrefType "journal-article" @default.
• W3027366955 hasAuthorship W3027366955A5001067933 @default.
• W3027366955 hasAuthorship W3027366955A5012569105 @default.
• W3027366955 hasAuthorship W3027366955A5026310393 @default.
• W3027366955 hasAuthorship W3027366955A5056937094 @default.
• W3027366955 hasAuthorship W3027366955A5059975383 @default.
• W3027366955 hasAuthorship W3027366955A5089324678 @default.
• W3027366955 hasAuthorship W3027366955A5089782295 @default.
• W3027366955 hasBestOaLocation W30273669551 @default.
• W3027366955 hasConcept C126322002 @default.
• W3027366955 hasConcept C131872663 @default.
• W3027366955 hasConcept C134018914 @default.
• W3027366955 hasConcept C201903717 @default.
• W3027366955 hasConcept C2778279030 @default.
• W3027366955 hasConcept C2779234561 @default.
• W3027366955 hasConcept C2908647359 @default.
• W3027366955 hasConcept C2908892503 @default.
• W3027366955 hasConcept C44249647 @default.
• W3027366955 hasConcept C54355233 @default.
• W3027366955 hasConcept C555293320 @default.
• W3027366955 hasConcept C71924100 @default.
• W3027366955 hasConcept C72563966 @default.
• W3027366955 hasConcept C73269764 @default.
• W3027366955 hasConcept C82789193 @default.
• W3027366955 hasConcept C86803240 @default.
• W3027366955 hasConcept C99454951 @default.

• next