Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027368652> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3027368652 endingPage "350" @default.
- W3027368652 startingPage "344" @default.
- W3027368652 abstract "Chronic opioid use is common and can cause opioid-induced esophageal dysfunction (OIED). We will discuss the pathophysiology, diagnosis, and management of OIED.OIED is diagnosed based on symptoms, opioid use, and manometric evidence of distal esophageal spasm, esophagogastric junction outflow obstruction, achalasia type III, or jackhammer esophagus. Chronic opioid use appears to interfere with inhibitory signals involved in control of esophageal motility, allowing for unchecked excitatory stimuli, and leading to spastic contractility and impaired esophagogastric junction relaxation. Patients may present with dysphagia and chest pain. OIED is significantly more prevalent in patients taking the stronger opioids oxycodone and hydrocodone compared with the weaker opioid tramadol. Based on 24-h morphine equivalent doses, patients with OIED take higher opioid doses than those without OIED. Impaired inhibitory signaling was recently demonstrated in a study showing reduced deglutitive inhibition during multiple rapid swallows in patients taking opioids.OIED is frequent in chronic opioid users undergoing manometry for esophageal symptoms, especially at higher doses or with stronger opioids. OIED appears to be due to impaired inhibitory signals in the esophagus. Opioid cessation or dose reduction is recommended, but studies examining management of OIED are lacking." @default.
- W3027368652 created "2020-05-29" @default.
- W3027368652 creator A5067663829 @default.
- W3027368652 creator A5080271414 @default.
- W3027368652 date "2020-05-13" @default.
- W3027368652 modified "2023-10-16" @default.
- W3027368652 title "Opioid-induced esophageal dysfunction" @default.
- W3027368652 cites W1583740121 @default.
- W3027368652 cites W1590608023 @default.
- W3027368652 cites W1648451107 @default.
- W3027368652 cites W1984775060 @default.
- W3027368652 cites W1994205098 @default.
- W3027368652 cites W1997961158 @default.
- W3027368652 cites W2010051841 @default.
- W3027368652 cites W2018817087 @default.
- W3027368652 cites W2031668128 @default.
- W3027368652 cites W2040832386 @default.
- W3027368652 cites W2050564812 @default.
- W3027368652 cites W2057243753 @default.
- W3027368652 cites W2066869240 @default.
- W3027368652 cites W2070479673 @default.
- W3027368652 cites W2086428468 @default.
- W3027368652 cites W2091753679 @default.
- W3027368652 cites W2093685229 @default.
- W3027368652 cites W2110791210 @default.
- W3027368652 cites W2152354642 @default.
- W3027368652 cites W2296986887 @default.
- W3027368652 cites W2319847981 @default.
- W3027368652 cites W2588766647 @default.
- W3027368652 cites W2914548239 @default.
- W3027368652 cites W2938661957 @default.
- W3027368652 cites W2956066103 @default.
- W3027368652 cites W2966959510 @default.
- W3027368652 cites W2967474472 @default.
- W3027368652 cites W4247081999 @default.
- W3027368652 doi "https://doi.org/10.1097/mog.0000000000000648" @default.
- W3027368652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32427604" @default.
- W3027368652 hasPublicationYear "2020" @default.
- W3027368652 type Work @default.
- W3027368652 sameAs 3027368652 @default.
- W3027368652 citedByCount "18" @default.
- W3027368652 countsByYear W30273686522021 @default.
- W3027368652 countsByYear W30273686522022 @default.
- W3027368652 countsByYear W30273686522023 @default.
- W3027368652 crossrefType "journal-article" @default.
- W3027368652 hasAuthorship W3027368652A5067663829 @default.
- W3027368652 hasAuthorship W3027368652A5080271414 @default.
- W3027368652 hasConcept C118552586 @default.
- W3027368652 hasConcept C126322002 @default.
- W3027368652 hasConcept C141071460 @default.
- W3027368652 hasConcept C170493617 @default.
- W3027368652 hasConcept C2776109754 @default.
- W3027368652 hasConcept C2777819096 @default.
- W3027368652 hasConcept C2779958274 @default.
- W3027368652 hasConcept C2780596822 @default.
- W3027368652 hasConcept C2781063702 @default.
- W3027368652 hasConcept C2781118164 @default.
- W3027368652 hasConcept C42219234 @default.
- W3027368652 hasConcept C71924100 @default.
- W3027368652 hasConceptScore W3027368652C118552586 @default.
- W3027368652 hasConceptScore W3027368652C126322002 @default.
- W3027368652 hasConceptScore W3027368652C141071460 @default.
- W3027368652 hasConceptScore W3027368652C170493617 @default.
- W3027368652 hasConceptScore W3027368652C2776109754 @default.
- W3027368652 hasConceptScore W3027368652C2777819096 @default.
- W3027368652 hasConceptScore W3027368652C2779958274 @default.
- W3027368652 hasConceptScore W3027368652C2780596822 @default.
- W3027368652 hasConceptScore W3027368652C2781063702 @default.
- W3027368652 hasConceptScore W3027368652C2781118164 @default.
- W3027368652 hasConceptScore W3027368652C42219234 @default.
- W3027368652 hasConceptScore W3027368652C71924100 @default.
- W3027368652 hasIssue "4" @default.
- W3027368652 hasLocation W30273686521 @default.
- W3027368652 hasLocation W30273686522 @default.
- W3027368652 hasOpenAccess W3027368652 @default.
- W3027368652 hasPrimaryLocation W30273686521 @default.
- W3027368652 hasRelatedWork W128085835 @default.
- W3027368652 hasRelatedWork W1979558461 @default.
- W3027368652 hasRelatedWork W1998582609 @default.
- W3027368652 hasRelatedWork W2090592228 @default.
- W3027368652 hasRelatedWork W2111799309 @default.
- W3027368652 hasRelatedWork W2268472639 @default.
- W3027368652 hasRelatedWork W2414106284 @default.
- W3027368652 hasRelatedWork W2414561108 @default.
- W3027368652 hasRelatedWork W2423233162 @default.
- W3027368652 hasRelatedWork W2730020983 @default.
- W3027368652 hasVolume "36" @default.
- W3027368652 isParatext "false" @default.
- W3027368652 isRetracted "false" @default.
- W3027368652 magId "3027368652" @default.
- W3027368652 workType "article" @default.