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• W3027390147 abstract "Contemporary studies of systemic sclerosis (SSc) consistently demonstrate that interstitial lung (ILD) is a leading cause of disease-related death. This review summarizes morbidity and mortality outcomes in SSc-ILD patients from high-quality observational and interventional studies over the last 50 years. The data presented suggest a trend for improved morbidity and mortality outcomes among present day SSc-ILD patients. Specifically, SSc-ILD patients appear to be living longer from the time of the initial diagnosis. Despite improved survival, the number one cause of death for most SSc-ILD patients remains respiratory failure from ILD. This review describes the most important demographic, clinical, and biological factors, which affect mortality in SSc-ILD, and could be used to help stratify patients for closer monitoring and more aggressive initial treatment. The review concludes with an overview of future research needed to (1) understand how to personalize the care of SSc-ILD patients to improve morbidity and mortality outcomes; and (2) investigate whether novel therapeutic interventions (e.g., anti-fibrotics, hematopoetic stem-cell transplantation) offer any meaningful long-term survival advantage over the current standard of care." @default.
• W3027390147 created "2020-05-29" @default.
• W3027390147 creator A5018731653 @default.
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• W3027390147 date "2020-05-22" @default.
• W3027390147 modified "2023-10-16" @default.
• W3027390147 title "Update on morbidity and mortality in systemic sclerosis–related interstitial lung disease" @default.
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• W3027390147 doi "https://doi.org/10.1177/2397198320915042" @default.
• W3027390147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7943067" @default.
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• W3027390147 hasPublicationYear "2020" @default.
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