Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027433515> ?p ?o ?g. }
- W3027433515 endingPage "484" @default.
- W3027433515 startingPage "475" @default.
- W3027433515 abstract "Abstract The loss of muscle mass and function with age, termed sarcopenia, is an inevitable process, which has a significant impact on quality of life. During ageing we observe a progressive loss of total muscle fibres and a reduction in cross-sectional area of the remaining fibres, resulting in a significant reduction in force output. The mechanisms which underpin sarcopenia are complex and poorly understood, ranging from inflammation, dysregulation of protein metabolism and denervation. However, there is significant evidence to demonstrate that modified ROS generation, redox dis-homeostasis and mitochondrial dysfunction may have an important role to play. Based on this, significant interest and research has interrogated potential ROS-targeted therapies, ranging from nutritional-based interventions such as vitamin E/C, polyphenols (resveratrol) and targeted pharmacological compounds, using molecules such as SS-31 and MitoQ. In this review we evaluate these approaches to target aberrant age-related ROS generation and the impact on muscle mass and function." @default.
- W3027433515 created "2020-05-29" @default.
- W3027433515 creator A5063324175 @default.
- W3027433515 creator A5069786778 @default.
- W3027433515 creator A5081133782 @default.
- W3027433515 creator A5083521022 @default.
- W3027433515 date "2020-05-23" @default.
- W3027433515 modified "2023-10-06" @default.
- W3027433515 title "Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function" @default.
- W3027433515 cites W1454913088 @default.
- W3027433515 cites W1500436940 @default.
- W3027433515 cites W1511189929 @default.
- W3027433515 cites W1575773325 @default.
- W3027433515 cites W1957992664 @default.
- W3027433515 cites W1963782920 @default.
- W3027433515 cites W1965891907 @default.
- W3027433515 cites W1973811144 @default.
- W3027433515 cites W1976663715 @default.
- W3027433515 cites W1983078193 @default.
- W3027433515 cites W1987892459 @default.
- W3027433515 cites W1990435249 @default.
- W3027433515 cites W1991912822 @default.
- W3027433515 cites W1997591046 @default.
- W3027433515 cites W1999218428 @default.
- W3027433515 cites W1999765859 @default.
- W3027433515 cites W2000723048 @default.
- W3027433515 cites W2004643937 @default.
- W3027433515 cites W2009973172 @default.
- W3027433515 cites W2010243470 @default.
- W3027433515 cites W2010524294 @default.
- W3027433515 cites W2012992792 @default.
- W3027433515 cites W2024780541 @default.
- W3027433515 cites W2042299953 @default.
- W3027433515 cites W2054511417 @default.
- W3027433515 cites W2055006202 @default.
- W3027433515 cites W2055456981 @default.
- W3027433515 cites W2062048222 @default.
- W3027433515 cites W2066016132 @default.
- W3027433515 cites W2068685393 @default.
- W3027433515 cites W2073341228 @default.
- W3027433515 cites W2079923716 @default.
- W3027433515 cites W2087350238 @default.
- W3027433515 cites W2097103188 @default.
- W3027433515 cites W2099375619 @default.
- W3027433515 cites W2101288007 @default.
- W3027433515 cites W2106373992 @default.
- W3027433515 cites W2116294028 @default.
- W3027433515 cites W2117396891 @default.
- W3027433515 cites W2117517043 @default.
- W3027433515 cites W2119019176 @default.
- W3027433515 cites W2119448420 @default.
- W3027433515 cites W2126521867 @default.
- W3027433515 cites W2132098985 @default.
- W3027433515 cites W2138458578 @default.
- W3027433515 cites W2140014506 @default.
- W3027433515 cites W2146587608 @default.
- W3027433515 cites W2183186491 @default.
- W3027433515 cites W2287626946 @default.
- W3027433515 cites W2293396461 @default.
- W3027433515 cites W2320203427 @default.
- W3027433515 cites W2400228013 @default.
- W3027433515 cites W2461769126 @default.
- W3027433515 cites W2476546019 @default.
- W3027433515 cites W2508689061 @default.
- W3027433515 cites W2509273744 @default.
- W3027433515 cites W2525933343 @default.
- W3027433515 cites W2552756863 @default.
- W3027433515 cites W2613221587 @default.
- W3027433515 cites W2617233822 @default.
- W3027433515 cites W2738955684 @default.
- W3027433515 cites W2739260540 @default.
- W3027433515 cites W2775218043 @default.
- W3027433515 cites W2797023968 @default.
- W3027433515 cites W2804108117 @default.
- W3027433515 cites W2810587571 @default.
- W3027433515 cites W2890207510 @default.
- W3027433515 cites W2895787947 @default.
- W3027433515 cites W2901183439 @default.
- W3027433515 cites W2908316563 @default.
- W3027433515 cites W2954353299 @default.
- W3027433515 cites W2967484716 @default.
- W3027433515 cites W2990148616 @default.
- W3027433515 cites W4300198507 @default.
- W3027433515 cites W62327953 @default.
- W3027433515 doi "https://doi.org/10.1007/s10522-020-09883-x" @default.
- W3027433515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7347670" @default.
- W3027433515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32447556" @default.
- W3027433515 hasPublicationYear "2020" @default.
- W3027433515 type Work @default.
- W3027433515 sameAs 3027433515 @default.
- W3027433515 citedByCount "26" @default.
- W3027433515 countsByYear W30274335152020 @default.
- W3027433515 countsByYear W30274335152021 @default.
- W3027433515 countsByYear W30274335152022 @default.
- W3027433515 countsByYear W30274335152023 @default.
- W3027433515 crossrefType "journal-article" @default.
- W3027433515 hasAuthorship W3027433515A5063324175 @default.
- W3027433515 hasAuthorship W3027433515A5069786778 @default.