Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027461886> ?p ?o ?g. }
- W3027461886 endingPage "14972" @default.
- W3027461886 startingPage "14965" @default.
- W3027461886 abstract "Abstract Dynamic combinatorial libraries (DCLs) is a powerful tool for ligand discovery in biomedical research; however, the application of DCLs has been hampered by their low diversity. Recently, the concept of DNA encoding has been employed in DCLs to create DNA‐encoded dynamic libraries (DEDLs); however, all current DEDLs are limited to fragment identification, and a challenging process of fragment linking is required after selection. We report an anchor‐directed DEDL approach that can identify full ligand structures from large‐scale DEDLs. This method is also able to convert unbiased libraries into focused ones targeting specific protein classes. We demonstrated this method by selecting DEDLs against five proteins, and novel inhibitors were identified for all targets. Notably, several selective BD1/BD2 inhibitors were identified from the selections against bromodomain 4 (BRD4), an important anti‐cancer drug target. This work may provide a broadly applicable method for inhibitor discovery." @default.
- W3027461886 created "2020-05-29" @default.
- W3027461886 creator A5000246832 @default.
- W3027461886 creator A5020692032 @default.
- W3027461886 creator A5025160935 @default.
- W3027461886 creator A5027842973 @default.
- W3027461886 creator A5029095757 @default.
- W3027461886 creator A5034299922 @default.
- W3027461886 creator A5040333789 @default.
- W3027461886 creator A5048407616 @default.
- W3027461886 creator A5079969301 @default.
- W3027461886 creator A5082020327 @default.
- W3027461886 creator A5084177862 @default.
- W3027461886 creator A5091910133 @default.
- W3027461886 date "2020-06-12" @default.
- W3027461886 modified "2023-10-17" @default.
- W3027461886 title "Selection of DNA‐Encoded Dynamic Chemical Libraries for Direct Inhibitor Discovery" @default.
- W3027461886 cites W1763517808 @default.
- W3027461886 cites W1968753037 @default.
- W3027461886 cites W1976353819 @default.
- W3027461886 cites W1979360726 @default.
- W3027461886 cites W1983153015 @default.
- W3027461886 cites W1984341645 @default.
- W3027461886 cites W1997595326 @default.
- W3027461886 cites W1998833443 @default.
- W3027461886 cites W2001217308 @default.
- W3027461886 cites W2014367004 @default.
- W3027461886 cites W2014599804 @default.
- W3027461886 cites W2015476695 @default.
- W3027461886 cites W2017423606 @default.
- W3027461886 cites W2019337771 @default.
- W3027461886 cites W2020620304 @default.
- W3027461886 cites W2020725709 @default.
- W3027461886 cites W2023262706 @default.
- W3027461886 cites W2028109844 @default.
- W3027461886 cites W2029077569 @default.
- W3027461886 cites W2034078336 @default.
- W3027461886 cites W2036005030 @default.
- W3027461886 cites W2039848673 @default.
- W3027461886 cites W2041535798 @default.
- W3027461886 cites W2042931146 @default.
- W3027461886 cites W2044352098 @default.
- W3027461886 cites W2052052881 @default.
- W3027461886 cites W2056705191 @default.
- W3027461886 cites W2058487969 @default.
- W3027461886 cites W2065633704 @default.
- W3027461886 cites W2068192680 @default.
- W3027461886 cites W2089902554 @default.
- W3027461886 cites W2095453782 @default.
- W3027461886 cites W2120520995 @default.
- W3027461886 cites W2125599832 @default.
- W3027461886 cites W2128753798 @default.
- W3027461886 cites W2137216204 @default.
- W3027461886 cites W2142607208 @default.
- W3027461886 cites W2146910635 @default.
- W3027461886 cites W2148510145 @default.
- W3027461886 cites W2151010843 @default.
- W3027461886 cites W2154980023 @default.
- W3027461886 cites W2168582787 @default.
- W3027461886 cites W2175115122 @default.
- W3027461886 cites W2286829287 @default.
- W3027461886 cites W2319763534 @default.
- W3027461886 cites W2467779447 @default.
- W3027461886 cites W2560551164 @default.
- W3027461886 cites W2562376843 @default.
- W3027461886 cites W2568322231 @default.
- W3027461886 cites W2587935821 @default.
- W3027461886 cites W2613253068 @default.
- W3027461886 cites W2619829249 @default.
- W3027461886 cites W2730372092 @default.
- W3027461886 cites W2758318460 @default.
- W3027461886 cites W2782995788 @default.
- W3027461886 cites W2795942127 @default.
- W3027461886 cites W2808696043 @default.
- W3027461886 cites W2890949632 @default.
- W3027461886 cites W2898858516 @default.
- W3027461886 cites W2917836509 @default.
- W3027461886 cites W2918761680 @default.
- W3027461886 cites W2921938159 @default.
- W3027461886 cites W2953873379 @default.
- W3027461886 cites W2981109304 @default.
- W3027461886 cites W4210631451 @default.
- W3027461886 cites W4231014422 @default.
- W3027461886 cites W4232466409 @default.
- W3027461886 cites W4233184616 @default.
- W3027461886 cites W4233548753 @default.
- W3027461886 cites W4253434940 @default.
- W3027461886 cites W4362017974 @default.
- W3027461886 cites W4383497367 @default.
- W3027461886 doi "https://doi.org/10.1002/anie.202005070" @default.
- W3027461886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32436364" @default.
- W3027461886 hasPublicationYear "2020" @default.
- W3027461886 type Work @default.
- W3027461886 sameAs 3027461886 @default.
- W3027461886 citedByCount "37" @default.
- W3027461886 countsByYear W30274618862020 @default.
- W3027461886 countsByYear W30274618862021 @default.
- W3027461886 countsByYear W30274618862022 @default.