Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027513059> ?p ?o ?g. }
- W3027513059 endingPage "103746" @default.
- W3027513059 startingPage "103746" @default.
- W3027513059 abstract "Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by binding to and regulating the functions of cellular and viral RNA and proteins. In teleost fish, knowledge about genes and functions of IFITs is currently limited. In the present work, we describe an IFIT5 orthologue in Atlantic salmon (SsaIFIT5) with characteristic tetratricopeptide repeat motifs. We show here that the gene encoding SsaIFIT5 (SsaIfit5) was ubiquitously expressed in various salmon tissues, while bacterial and viral challenge of live fish and in vitro stimulation of cells with recombinant IFNs and pathogen mimics triggered its transcription. The profound expression in response to various immune stimulation could be ascribed to the identified IFN response elements and binding sites for various immune-relevant transcription factors in the putative promoter of the SsaIfit5 gene. Our results establish SsaIfit5 as an IFN-stimulated gene in A. salmon and strongly suggest a phylogenetically conserved role of the IFIT5 protein in antimicrobial responses in vertebrates." @default.
- W3027513059 created "2020-05-29" @default.
- W3027513059 creator A5000607923 @default.
- W3027513059 creator A5023717901 @default.
- W3027513059 creator A5041960681 @default.
- W3027513059 creator A5052159087 @default.
- W3027513059 creator A5056619889 @default.
- W3027513059 creator A5066475013 @default.
- W3027513059 date "2020-10-01" @default.
- W3027513059 modified "2023-09-26" @default.
- W3027513059 title "Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish" @default.
- W3027513059 cites W1490200235 @default.
- W3027513059 cites W1595056978 @default.
- W3027513059 cites W1733534154 @default.
- W3027513059 cites W1966902552 @default.
- W3027513059 cites W1967575570 @default.
- W3027513059 cites W1971800474 @default.
- W3027513059 cites W1977270364 @default.
- W3027513059 cites W1977454357 @default.
- W3027513059 cites W1988393300 @default.
- W3027513059 cites W1989309079 @default.
- W3027513059 cites W1989392037 @default.
- W3027513059 cites W1991186601 @default.
- W3027513059 cites W1991728167 @default.
- W3027513059 cites W1992128599 @default.
- W3027513059 cites W1997685308 @default.
- W3027513059 cites W2004727967 @default.
- W3027513059 cites W2006439216 @default.
- W3027513059 cites W2006924047 @default.
- W3027513059 cites W2010489495 @default.
- W3027513059 cites W2013958910 @default.
- W3027513059 cites W2016039354 @default.
- W3027513059 cites W2018380716 @default.
- W3027513059 cites W2019077744 @default.
- W3027513059 cites W2021605176 @default.
- W3027513059 cites W2024041718 @default.
- W3027513059 cites W2033082876 @default.
- W3027513059 cites W2035124958 @default.
- W3027513059 cites W2035509260 @default.
- W3027513059 cites W2036369869 @default.
- W3027513059 cites W2037312364 @default.
- W3027513059 cites W2038459819 @default.
- W3027513059 cites W2040551905 @default.
- W3027513059 cites W2044818544 @default.
- W3027513059 cites W2051249607 @default.
- W3027513059 cites W2053164681 @default.
- W3027513059 cites W2058492139 @default.
- W3027513059 cites W2063310200 @default.
- W3027513059 cites W2064233919 @default.
- W3027513059 cites W2066728093 @default.
- W3027513059 cites W2069794084 @default.
- W3027513059 cites W2073187732 @default.
- W3027513059 cites W2074025680 @default.
- W3027513059 cites W2075300931 @default.
- W3027513059 cites W2075413744 @default.
- W3027513059 cites W2076039408 @default.
- W3027513059 cites W2076198632 @default.
- W3027513059 cites W2081482622 @default.
- W3027513059 cites W2085459501 @default.
- W3027513059 cites W2086004955 @default.
- W3027513059 cites W2086941795 @default.
- W3027513059 cites W2094458603 @default.
- W3027513059 cites W2106753580 @default.
- W3027513059 cites W2107779325 @default.
- W3027513059 cites W2114570899 @default.
- W3027513059 cites W2120588017 @default.
- W3027513059 cites W2121608531 @default.
- W3027513059 cites W2127848114 @default.
- W3027513059 cites W2131048729 @default.
- W3027513059 cites W2133402546 @default.
- W3027513059 cites W2134768631 @default.
- W3027513059 cites W2137259658 @default.
- W3027513059 cites W2141659272 @default.
- W3027513059 cites W2145149844 @default.
- W3027513059 cites W2145221987 @default.
- W3027513059 cites W2148240014 @default.
- W3027513059 cites W2150562936 @default.
- W3027513059 cites W2153550523 @default.
- W3027513059 cites W2154164244 @default.
- W3027513059 cites W2222527861 @default.
- W3027513059 cites W2547175145 @default.
- W3027513059 cites W2587679275 @default.
- W3027513059 cites W2791568735 @default.
- W3027513059 cites W2802897459 @default.
- W3027513059 cites W2890637273 @default.
- W3027513059 cites W2891165344 @default.
- W3027513059 cites W2914739296 @default.
- W3027513059 cites W2922286507 @default.
- W3027513059 cites W2936366192 @default.
- W3027513059 cites W568682068 @default.
- W3027513059 doi "https://doi.org/10.1016/j.dci.2020.103746" @default.
- W3027513059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32445651" @default.
- W3027513059 hasPublicationYear "2020" @default.
- W3027513059 type Work @default.
- W3027513059 sameAs 3027513059 @default.
- W3027513059 citedByCount "3" @default.
- W3027513059 countsByYear W30275130592022 @default.
- W3027513059 countsByYear W30275130592023 @default.