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• W3027599797 abstract "Evidence bearing on the importance of the renin/angiotensin system in the regulation of aldosterone secretion in man is reviewed. Elevation of plasma angiotensin II concentration in simple dietary sodium deprivation has been confirmed. In primary renin deficiency, both angiotensin II and aldosterone are deficient. In these circumstances plasma aldosterone can remain unresponsive to very large rises in plasma potassium, but increase promptly on infusion of angiotensin II. Sodium depletion in normal man increases the adrenocortical sensitivity to angiotensin II, while diminishing the pressor effect. The NaE/renin and NaE/angiotensin II interrelations are normal in primary hyper-aldosteronism both before and after treatment, and also in untreated essential hypertension with normal renin levels. These relationships are depressed in low-renin essential hypertension. In renal and malignant hypertension the relationships are enhanced. In renal and malignant hypertension the angiotensin II-pressor relationship is enhanced, and the angiotensin II–aldosterone relationship steepened as compared with normal subjects acutely infused with angiotensin. A hypothetical mechanism for the suppression of renin in essential hypertension is outlined." @default.
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• W3027599797 date "1976-01-01" @default.
• W3027599797 modified "2023-10-16" @default.
• W3027599797 title "INTER-RELATIONSHIPS BETWEEN PLASMA ANGIOTENSIN II, ARTERIAL PRESSURE, ALDOSTERONE AND EXCHANGEABLE SODIUM IN NORMOTENSIVE AND HYPERTENSIVE MAN" @default.
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• W3027599797 doi "https://doi.org/10.1016/b978-0-08-019682-4.50102-5" @default.
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