FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027603955> ?p ?o ?g. }

• W3027603955 endingPage "1214" @default.
• W3027603955 startingPage "1207" @default.
• W3027603955 abstract "Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimmunology. Here, we examined the effects of S1P on IL-6 expression in osteoblasts. Our results and records from the Gene Expression Omnibus (GEO) database demonstrate higher levels of IL-6 in patients with RA compared with those with osteoarthritis. Stimulation of osteoblasts with S1P increased mRNA and protein expression of IL-6. PI3K, MEK, ERK and NF-κB inhibitors and their small interfering RNAs (siRNAs) reduced S1P-promoted IL-6 expression. S1P also facilitated PI3K, MEK/ERK and NF-κB signaling cascades. Our results indicate that S1P promotes the expression of IL-6 in osteoblasts via the PI3K, MEK/ERK and NF-κB signaling pathways." @default.
• W3027603955 created "2020-05-29" @default.
• W3027603955 creator A5014950143 @default.
• W3027603955 creator A5039601728 @default.
• W3027603955 creator A5063673449 @default.
• W3027603955 creator A5066639832 @default.
• W3027603955 creator A5075455921 @default.
• W3027603955 creator A5076096342 @default.
• W3027603955 creator A5085507861 @default.
• W3027603955 date "2020-01-01" @default.
• W3027603955 modified "2023-10-01" @default.
• W3027603955 title "S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways" @default.
• W3027603955 cites W1932410428 @default.
• W3027603955 cites W2046620357 @default.
• W3027603955 cites W2080832501 @default.
• W3027603955 cites W2097147259 @default.
• W3027603955 cites W2100041813 @default.
• W3027603955 cites W2105008533 @default.
• W3027603955 cites W2117262962 @default.
• W3027603955 cites W2121567901 @default.
• W3027603955 cites W2142563473 @default.
• W3027603955 cites W2148145940 @default.
• W3027603955 cites W2154642413 @default.
• W3027603955 cites W2209309946 @default.
• W3027603955 cites W2318945923 @default.
• W3027603955 cites W2327312897 @default.
• W3027603955 cites W2336588424 @default.
• W3027603955 cites W2341257746 @default.
• W3027603955 cites W2498527063 @default.
• W3027603955 cites W2603064549 @default.
• W3027603955 cites W2615601352 @default.
• W3027603955 cites W2727398384 @default.
• W3027603955 cites W2783127674 @default.
• W3027603955 cites W2801873840 @default.
• W3027603955 cites W2863976931 @default.
• W3027603955 cites W2884972179 @default.
• W3027603955 cites W2885964716 @default.
• W3027603955 cites W2890934004 @default.
• W3027603955 cites W2901399649 @default.
• W3027603955 cites W2911161333 @default.
• W3027603955 cites W2925920308 @default.
• W3027603955 cites W2938774134 @default.
• W3027603955 cites W2944216054 @default.
• W3027603955 cites W2946527981 @default.
• W3027603955 cites W2948070094 @default.
• W3027603955 cites W2954096447 @default.
• W3027603955 cites W2995300252 @default.
• W3027603955 doi "https://doi.org/10.7150/ijms.44612" @default.
• W3027603955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7294913" @default.
• W3027603955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32547316" @default.
• W3027603955 hasPublicationYear "2020" @default.
• W3027603955 type Work @default.
• W3027603955 sameAs 3027603955 @default.
• W3027603955 citedByCount "17" @default.
• W3027603955 countsByYear W30276039552020 @default.
• W3027603955 countsByYear W30276039552021 @default.
• W3027603955 countsByYear W30276039552022 @default.
• W3027603955 countsByYear W30276039552023 @default.
• W3027603955 crossrefType "journal-article" @default.
• W3027603955 hasAuthorship W3027603955A5014950143 @default.
• W3027603955 hasAuthorship W3027603955A5039601728 @default.
• W3027603955 hasAuthorship W3027603955A5063673449 @default.
• W3027603955 hasAuthorship W3027603955A5066639832 @default.
• W3027603955 hasAuthorship W3027603955A5075455921 @default.
• W3027603955 hasAuthorship W3027603955A5076096342 @default.
• W3027603955 hasAuthorship W3027603955A5085507861 @default.
• W3027603955 hasBestOaLocation W30276039551 @default.
• W3027603955 hasConcept C185592680 @default.
• W3027603955 hasConcept C202751555 @default.
• W3027603955 hasConcept C2777730290 @default.
• W3027603955 hasConcept C2778260815 @default.
• W3027603955 hasConcept C502942594 @default.
• W3027603955 hasConcept C55493867 @default.
• W3027603955 hasConcept C57074206 @default.
• W3027603955 hasConcept C62478195 @default.
• W3027603955 hasConcept C86554907 @default.
• W3027603955 hasConcept C86803240 @default.
• W3027603955 hasConcept C95444343 @default.
• W3027603955 hasConceptScore W3027603955C185592680 @default.
• W3027603955 hasConceptScore W3027603955C202751555 @default.
• W3027603955 hasConceptScore W3027603955C2777730290 @default.
• W3027603955 hasConceptScore W3027603955C2778260815 @default.
• W3027603955 hasConceptScore W3027603955C502942594 @default.
• W3027603955 hasConceptScore W3027603955C55493867 @default.
• W3027603955 hasConceptScore W3027603955C57074206 @default.
• W3027603955 hasConceptScore W3027603955C62478195 @default.
• W3027603955 hasConceptScore W3027603955C86554907 @default.
• W3027603955 hasConceptScore W3027603955C86803240 @default.
• W3027603955 hasConceptScore W3027603955C95444343 @default.
• W3027603955 hasIssue "9" @default.
• W3027603955 hasLocation W30276039551 @default.
• W3027603955 hasLocation W30276039552 @default.
• W3027603955 hasLocation W30276039553 @default.
• W3027603955 hasOpenAccess W3027603955 @default.
• W3027603955 hasPrimaryLocation W30276039551 @default.
• W3027603955 hasRelatedWork W1978760124 @default.
• W3027603955 hasRelatedWork W2004726042 @default.
• W3027603955 hasRelatedWork W2024936926 @default.

• next