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• W3027635806 abstract "The effect of different framework topologies and aluminum contents on the release behavior of probucol was investigated using BEA, MFI and NaX as the microporous zeolite drug carriers. Post-drug loading changes in the textural properties of the zeolites and the crystalline state of probucol were evaluated using nitrogen adsorption–desorption measurements, differential scanning calorimetry and X-ray diffraction analysis. Results indicated significant drug amorphization upon loading in all zeolite types, with drug deposition occurring within the micropore channels and the external surface area of the microporous carriers. Molecular dynamics simulations were employed to delineate drug diffusion within the framework structure, showing that PB diffused more easily through the BEA pore network, compared to MFI, while drug's movement within NaX was almost negligible. The same trend was observed in the in vitro drug release profiles in simulated gastric fluid, indicating that aluminum content is a determinant factor in the extend of probucol release. NaX containing the highest aluminum content demonstrated less than 5% of probucol release, in contrast to BEA containing the lowest aluminum content for which almost total drug release was observed." @default.
• W3027635806 created "2020-05-29" @default.
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• W3027635806 date "2020-10-01" @default.
• W3027635806 modified "2023-10-13" @default.
• W3027635806 title "Experimental and molecular dynamics simulation studies of an anti-hyperlipidemic drug release from microporous zeolites differing in Si/Al content" @default.
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• W3027635806 doi "https://doi.org/10.1016/j.micromeso.2020.110343" @default.
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