FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027728806> ?p ?o ?g. }

• W3027728806 endingPage "9329" @default.
• W3027728806 startingPage "9318" @default.
• W3027728806 abstract "Recently, collagen triple helix repeat containing-1 (CTHRC1) has been reported to be increased in several types of human solid cancers and to be associated with tumor invasion and metastasis. However, the expression and function of CTHRC1 in glioma have not yet been reported. In the present study, we investigated whether CTHRC1 plays a role in glioma pathogenesis. Using the tissue microarray technology, we found that CTHRC1 expression is significantly increased in glioma compared with tumor adjacent normal brain tissue (P<0.01, χ2 test) and increased CTHRC1 staining was associated with WHO stages (P<0.05, χ2 test). The mRNA and protein levels of CTHRC1 were significantly upregulated in human primary glioma tissues (P<0.001, χ2 test). We also found that CTHRC1 was significantly increased in glioma cell lines compared to normal human astrocytes (P<0.01, χ2 test). Furthermore, Knockdown of CTHRC1 suppressed glioma cell invasion and inhibited enzyme activity of MMP-2. Moreover, our data showed that knockdown of CTHRC1 inhibited glioma cell migration and adhesion capacity when compared with the control cells, and CTHRC1-siRNA reduced the levels of phosphorylated Src and FAK protein expression. Taken together, this study suggests that CTHRC1 plays a role in glioma development and progression by regulating invasion, migration and adhesion capabilities of cancer cells." @default.
• W3027728806 created "2020-05-29" @default.
• W3027728806 creator A5004490784 @default.
• W3027728806 creator A5031638725 @default.
• W3027728806 creator A5053191076 @default.
• W3027728806 creator A5063253432 @default.
• W3027728806 creator A5066385548 @default.
• W3027728806 creator A5072548035 @default.
• W3027728806 creator A5084078831 @default.
• W3027728806 creator A5089275232 @default.
• W3027728806 date "2017-01-01" @default.
• W3027728806 modified "2023-09-27" @default.
• W3027728806 title "CTHRC1 mediates multiple pathways regulating cell invasion, migration and adhesion in glioma." @default.
• W3027728806 cites W1430273632 @default.
• W3027728806 cites W147437292 @default.
• W3027728806 cites W1541427649 @default.
• W3027728806 cites W1890228288 @default.
• W3027728806 cites W1965037168 @default.
• W3027728806 cites W1969342647 @default.
• W3027728806 cites W1970227868 @default.
• W3027728806 cites W1973330653 @default.
• W3027728806 cites W1974777081 @default.
• W3027728806 cites W1985348583 @default.
• W3027728806 cites W1994567037 @default.
• W3027728806 cites W2002788388 @default.
• W3027728806 cites W2022448099 @default.
• W3027728806 cites W2025979262 @default.
• W3027728806 cites W2049132016 @default.
• W3027728806 cites W2049820772 @default.
• W3027728806 cites W2054976402 @default.
• W3027728806 cites W2058143190 @default.
• W3027728806 cites W2058240531 @default.
• W3027728806 cites W2061955385 @default.
• W3027728806 cites W2070186254 @default.
• W3027728806 cites W2073852343 @default.
• W3027728806 cites W2077672406 @default.
• W3027728806 cites W2096783707 @default.
• W3027728806 cites W2113578264 @default.
• W3027728806 cites W2126764080 @default.
• W3027728806 cites W2139304914 @default.
• W3027728806 cites W2143908316 @default.
• W3027728806 cites W2144273675 @default.
• W3027728806 cites W2155460347 @default.
• W3027728806 cites W2159956387 @default.
• W3027728806 cites W2230620427 @default.
• W3027728806 cites W2272984102 @default.
• W3027728806 cites W2552237749 @default.
• W3027728806 cites W2569361595 @default.
• W3027728806 cites W2532753986 @default.
• W3027728806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6965956" @default.
• W3027728806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31966804" @default.
• W3027728806 hasPublicationYear "2017" @default.
• W3027728806 type Work @default.
• W3027728806 sameAs 3027728806 @default.
• W3027728806 citedByCount "2" @default.
• W3027728806 countsByYear W30277288062022 @default.
• W3027728806 crossrefType "journal-article" @default.
• W3027728806 hasAuthorship W3027728806A5004490784 @default.
• W3027728806 hasAuthorship W3027728806A5031638725 @default.
• W3027728806 hasAuthorship W3027728806A5053191076 @default.
• W3027728806 hasAuthorship W3027728806A5063253432 @default.
• W3027728806 hasAuthorship W3027728806A5066385548 @default.
• W3027728806 hasAuthorship W3027728806A5072548035 @default.
• W3027728806 hasAuthorship W3027728806A5084078831 @default.
• W3027728806 hasAuthorship W3027728806A5089275232 @default.
• W3027728806 hasConcept C104317684 @default.
• W3027728806 hasConcept C121608353 @default.
• W3027728806 hasConcept C127561419 @default.
• W3027728806 hasConcept C137738243 @default.
• W3027728806 hasConcept C142724271 @default.
• W3027728806 hasConcept C1491633281 @default.
• W3027728806 hasConcept C173396325 @default.
• W3027728806 hasConcept C2778227246 @default.
• W3027728806 hasConcept C2779013556 @default.
• W3027728806 hasConcept C502942594 @default.
• W3027728806 hasConcept C54355233 @default.
• W3027728806 hasConcept C55493867 @default.
• W3027728806 hasConcept C71924100 @default.
• W3027728806 hasConcept C81885089 @default.
• W3027728806 hasConcept C85789140 @default.
• W3027728806 hasConcept C86803240 @default.
• W3027728806 hasConceptScore W3027728806C104317684 @default.
• W3027728806 hasConceptScore W3027728806C121608353 @default.
• W3027728806 hasConceptScore W3027728806C127561419 @default.
• W3027728806 hasConceptScore W3027728806C137738243 @default.
• W3027728806 hasConceptScore W3027728806C142724271 @default.
• W3027728806 hasConceptScore W3027728806C1491633281 @default.
• W3027728806 hasConceptScore W3027728806C173396325 @default.
• W3027728806 hasConceptScore W3027728806C2778227246 @default.
• W3027728806 hasConceptScore W3027728806C2779013556 @default.
• W3027728806 hasConceptScore W3027728806C502942594 @default.
• W3027728806 hasConceptScore W3027728806C54355233 @default.
• W3027728806 hasConceptScore W3027728806C55493867 @default.
• W3027728806 hasConceptScore W3027728806C71924100 @default.
• W3027728806 hasConceptScore W3027728806C81885089 @default.
• W3027728806 hasConceptScore W3027728806C85789140 @default.
• W3027728806 hasConceptScore W3027728806C86803240 @default.
• W3027728806 hasIssue "9" @default.

• next