Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027752479> ?p ?o ?g. }
- W3027752479 abstract "Abstract Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple aspects of the adaptive immune response to influenza have been well-documented including a decline in antibody responses to influenza vaccination and changes in the cell-mediated response associated with immune senescence. This review will focus on T cell responses to influenza and influenza vaccination in older adults, and how increasing frailty or coexistence of multiple (≥2) chronic conditions contributes to the loss of vaccine effectiveness for the prevention of hospitalization. Further, dysregulation of the production of pro- and anti-inflammatory mediators contributes to a decline in the generation of an effective CD8 T cell response needed to clear influenza virus from the lungs. Current influenza vaccines provide only a weak stimulus to this arm of the adaptive immune response and rely on re-stimulation of CD8 T cell memory related to prior exposure to influenza virus. Efforts to improve vaccine effectiveness in older adults will be fruitless until CD8 responses take center stage." @default.
- W3027752479 created "2020-05-29" @default.
- W3027752479 creator A5027331206 @default.
- W3027752479 creator A5043571067 @default.
- W3027752479 creator A5056759771 @default.
- W3027752479 creator A5075848918 @default.
- W3027752479 creator A5076470375 @default.
- W3027752479 creator A5088320309 @default.
- W3027752479 date "2020-05-07" @default.
- W3027752479 modified "2023-10-16" @default.
- W3027752479 title "The immune response to influenza in older humans: beyond immune senescence" @default.
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