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- W3027760079 abstract "We thank Drs Wu et al for their interest in our manuscript1 and the stimulating data they provide regarding the value of hydroxychloroquine (HCQ) in the prevention of chronic kidney disease (CKD) in patients with systemic lupus erythematosus (SLE).2 We agree with the authors that the evidence behind the recommendation for a 50% reduction in HCQ dose in patients with lupus nephritis (LN) and a glomerular filtration rate (GFR) less than 30% is not supported by high-level evidence (although it is known that excretion of the drug is carried out principally by direct renal clearance).3 4 Nevertheless, CKD is considered a risk factor for the most important side effect of HCQ, retinal toxicity ; …" @default.
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- W3027760079 date "2020-05-20" @default.
- W3027760079 modified "2023-09-27" @default.
- W3027760079 title "Response to: ‘Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus’ by Wuet al" @default.
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- W3027760079 doi "https://doi.org/10.1136/annrheumdis-2020-217804" @default.
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