FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027776412> ?p ?o ?g. }

• W3027776412 endingPage "5100" @default.
• W3027776412 startingPage "5091" @default.
• W3027776412 abstract "Objective To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats. Materials and methods A sevoflurane anesthesia-induced POCD aged rat model was established and hematoxylin and eosin (H&E) staining was used to detect pathological changes of hippocampal neurons. Morris water maze task test was performed to determine the learning and memory ability of rats. Immunofluorescence, quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot were used to detect CTRP3 expression. Enzyme-linked immunosorbent assay (ELISA) or qRT-PCR assays were used to evaluate the changes of markers of brain damage and inflammatory cytokines. Terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) assay was used to assess the apoptosis of nerve cells in hippocampus. Western blot assay were used to measure the expression levels of apoptosis-related protein, and AMP-activated protein kinase (AMPK)/SIRT1 and PI3K/AKT pathway. Results Sevoflurane exposure led to brain injury, cognitive dysfunction in aged rats and decreased the expression of CTRP3. Overexpression of CTRP3 could suppress nerve cell apoptosis, inhibit neuronal inflammation, reduce brain tissue damage and improve cognitive dysfunction of aged rats after sevoflurane anesthesia. Further studies showed that CTRP3 may play a role in POCD by regulating AMPK/SIRT1 and PI3K/AKT signaling pathways. Conclusions CTRP3 may effectively protect against sevoflurane-induced cognitive dysfunction and served as a potential predictive indicator and therapy target for POCD." @default.
• W3027776412 created "2020-05-29" @default.
• W3027776412 creator A5025067296 @default.
• W3027776412 creator A5032378268 @default.
• W3027776412 creator A5035418730 @default.
• W3027776412 date "2020-05-01" @default.
• W3027776412 modified "2023-09-26" @default.
• W3027776412 title "Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways." @default.
• W3027776412 doi "https://doi.org/10.26355/eurrev_202005_21202" @default.
• W3027776412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32432773" @default.
• W3027776412 hasPublicationYear "2020" @default.
• W3027776412 type Work @default.
• W3027776412 sameAs 3027776412 @default.
• W3027776412 citedByCount "11" @default.
• W3027776412 countsByYear W30277764122020 @default.
• W3027776412 countsByYear W30277764122021 @default.
• W3027776412 countsByYear W30277764122022 @default.
• W3027776412 countsByYear W30277764122023 @default.
• W3027776412 crossrefType "journal-article" @default.
• W3027776412 hasAuthorship W3027776412A5025067296 @default.
• W3027776412 hasAuthorship W3027776412A5032378268 @default.
• W3027776412 hasAuthorship W3027776412A5035418730 @default.
• W3027776412 hasConcept C104317684 @default.
• W3027776412 hasConcept C118552586 @default.
• W3027776412 hasConcept C134018914 @default.
• W3027776412 hasConcept C142724271 @default.
• W3027776412 hasConcept C169900460 @default.
• W3027776412 hasConcept C184235292 @default.
• W3027776412 hasConcept C185592680 @default.
• W3027776412 hasConcept C190283241 @default.
• W3027776412 hasConcept C196795494 @default.
• W3027776412 hasConcept C204232928 @default.
• W3027776412 hasConcept C25498285 @default.
• W3027776412 hasConcept C2776415932 @default.
• W3027776412 hasConcept C2780043718 @default.
• W3027776412 hasConcept C2780124434 @default.
• W3027776412 hasConcept C2781161787 @default.
• W3027776412 hasConcept C2781453256 @default.
• W3027776412 hasConcept C42219234 @default.
• W3027776412 hasConcept C44752575 @default.
• W3027776412 hasConcept C55493867 @default.
• W3027776412 hasConcept C71924100 @default.
• W3027776412 hasConcept C75217442 @default.
• W3027776412 hasConcept C86554907 @default.
• W3027776412 hasConcept C86803240 @default.
• W3027776412 hasConcept C95444343 @default.
• W3027776412 hasConcept C97029542 @default.
• W3027776412 hasConcept C98274493 @default.
• W3027776412 hasConceptScore W3027776412C104317684 @default.
• W3027776412 hasConceptScore W3027776412C118552586 @default.
• W3027776412 hasConceptScore W3027776412C134018914 @default.
• W3027776412 hasConceptScore W3027776412C142724271 @default.
• W3027776412 hasConceptScore W3027776412C169900460 @default.
• W3027776412 hasConceptScore W3027776412C184235292 @default.
• W3027776412 hasConceptScore W3027776412C185592680 @default.
• W3027776412 hasConceptScore W3027776412C190283241 @default.
• W3027776412 hasConceptScore W3027776412C196795494 @default.
• W3027776412 hasConceptScore W3027776412C204232928 @default.
• W3027776412 hasConceptScore W3027776412C25498285 @default.
• W3027776412 hasConceptScore W3027776412C2776415932 @default.
• W3027776412 hasConceptScore W3027776412C2780043718 @default.
• W3027776412 hasConceptScore W3027776412C2780124434 @default.
• W3027776412 hasConceptScore W3027776412C2781161787 @default.
• W3027776412 hasConceptScore W3027776412C2781453256 @default.
• W3027776412 hasConceptScore W3027776412C42219234 @default.
• W3027776412 hasConceptScore W3027776412C44752575 @default.
• W3027776412 hasConceptScore W3027776412C55493867 @default.
• W3027776412 hasConceptScore W3027776412C71924100 @default.
• W3027776412 hasConceptScore W3027776412C75217442 @default.
• W3027776412 hasConceptScore W3027776412C86554907 @default.
• W3027776412 hasConceptScore W3027776412C86803240 @default.
• W3027776412 hasConceptScore W3027776412C95444343 @default.
• W3027776412 hasConceptScore W3027776412C97029542 @default.
• W3027776412 hasConceptScore W3027776412C98274493 @default.
• W3027776412 hasIssue "9" @default.
• W3027776412 hasLocation W30277764121 @default.
• W3027776412 hasOpenAccess W3027776412 @default.
• W3027776412 hasPrimaryLocation W30277764121 @default.
• W3027776412 hasRelatedWork W1994318725 @default.
• W3027776412 hasRelatedWork W2031037143 @default.
• W3027776412 hasRelatedWork W2206238007 @default.
• W3027776412 hasRelatedWork W2494626312 @default.
• W3027776412 hasRelatedWork W2740524480 @default.
• W3027776412 hasRelatedWork W2775124792 @default.
• W3027776412 hasRelatedWork W2779232463 @default.
• W3027776412 hasRelatedWork W2786099180 @default.
• W3027776412 hasRelatedWork W2797762227 @default.
• W3027776412 hasRelatedWork W2805962694 @default.
• W3027776412 hasRelatedWork W2886958232 @default.
• W3027776412 hasRelatedWork W2902267205 @default.
• W3027776412 hasRelatedWork W2902289977 @default.
• W3027776412 hasRelatedWork W2902948091 @default.
• W3027776412 hasRelatedWork W2969118606 @default.
• W3027776412 hasRelatedWork W3031552308 @default.
• W3027776412 hasRelatedWork W3046936219 @default.
• W3027776412 hasRelatedWork W3047359230 @default.
• W3027776412 hasRelatedWork W3094239161 @default.
• W3027776412 hasRelatedWork W3197887701 @default.

• next