FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027832767> ?p ?o ?g. }

• W3027832767 endingPage "4130" @default.
• W3027832767 startingPage "4121" @default.
• W3027832767 abstract "Key points Highlanders develop unique adaptative mechanisms to chronic hypoxic exposure, including substantial haemoglobin and haematocrit increases. However, a significant proportion of populations living permanently at high altitude develop maladaptive features known as chronic mountain sickness (CMS). This study aimed to assess the effects of permanent life at high altitude on clinical and haemorheological parameters (blood viscosity and red blood cell aggregation) and to compare clinical and haemorheological parameters of dwellers from the highest city in the world according to CMS severity. Blood viscosity increased with altitude, together with haemoglobin concentration and haematocrit. At 5100 m, highlanders with moderate-to-severe CMS had higher blood viscosity mainly at high shear rate and even at corrected haematocrit (40%), with a lower red blood cell aggregation. Blood viscosity may contribute to CMS symptomatology but the increased blood viscosity in CMS patients cannot solely be explained by the rise in haematocrit. Abstract Chronic mountain sickness (CMS) is a condition characterised by excessive erythrocytosis (EE). While EE is thought to increase blood viscosity and subsequently to trigger CMS symptoms, the exact relationship between blood viscosity and CMS symptoms remains incompletely understood. We assessed the effect of living at high altitude on haemoglobin, haematocrit and haemorheological parameters (blood viscosity and red blood cell aggregation), and investigated their relationship with CMS in highlanders living in the highest city in the world (La Rinconada, Peru, 5100 m). Ninety-three men participated in this study: 10 Caucasian lowlanders, 13 Andean highlanders living at 3800 m and 70 Andean highlanders living at 5100 m (35 asymptomatic, CMS score ≤5; 15 with mild CMS, CMS score between 6 and 10; 20 with moderate-to-severe CMS, CMS score >10). Blood viscosity was measured at native and corrected haematocrit (40%). Haemoglobin concentration and haematocrit increased with the altitude of residency. Blood viscosity also increased with altitude (at 45 s−1: 6.7 ± 0.9 mPa s at sea level, 14.0 ± 2.0 mPa s at 3800 m and 27.1 ± 8.8 mPa s at 5100 m; P < 0.001). At 5100 m, blood viscosity at corrected haematocrit was higher in highlanders with moderate-to-severe CMS (at 45 s−1: 18.9 ± 10.7 mPa s) than in highlanders without CMS (10.2 ± 5.9 mPa s) or with mild CMS (12.1 ± 6.1 mPa s) (P < 0.05). In conclusion, blood viscosity may contribute to CMS symptomatology but the increased blood viscosity in CMS patients cannot solely be explained by the rise in haematocrit." @default.
• W3027832767 created "2020-05-29" @default.
• W3027832767 creator A5000775806 @default.
• W3027832767 creator A5002422164 @default.
• W3027832767 creator A5007696105 @default.
• W3027832767 creator A5009949348 @default.
• W3027832767 creator A5019289302 @default.
• W3027832767 creator A5020573984 @default.
• W3027832767 creator A5033827870 @default.
• W3027832767 creator A5035845233 @default.
• W3027832767 creator A5061653786 @default.
• W3027832767 creator A5074850666 @default.
• W3027832767 creator A5080646983 @default.
• W3027832767 creator A5082755711 @default.
• W3027832767 creator A5086806040 @default.
• W3027832767 date "2020-06-14" @default.
• W3027832767 modified "2023-09-23" @default.
• W3027832767 title "Blood viscosity and its determinants in the highest city in the world" @default.
• W3027832767 cites W1503318521 @default.
• W3027832767 cites W1538001481 @default.
• W3027832767 cites W1580377017 @default.
• W3027832767 cites W1783041169 @default.
• W3027832767 cites W1925894237 @default.
• W3027832767 cites W1971969349 @default.
• W3027832767 cites W1985989416 @default.
• W3027832767 cites W2009827786 @default.
• W3027832767 cites W2020315314 @default.
• W3027832767 cites W2026334890 @default.
• W3027832767 cites W2038578558 @default.
• W3027832767 cites W2039761027 @default.
• W3027832767 cites W2051697737 @default.
• W3027832767 cites W2053892993 @default.
• W3027832767 cites W2074656530 @default.
• W3027832767 cites W2078074521 @default.
• W3027832767 cites W2091107957 @default.
• W3027832767 cites W2091484032 @default.
• W3027832767 cites W2102965718 @default.
• W3027832767 cites W2107985522 @default.
• W3027832767 cites W2119536526 @default.
• W3027832767 cites W2128703021 @default.
• W3027832767 cites W2142738495 @default.
• W3027832767 cites W2182735347 @default.
• W3027832767 cites W2210742289 @default.
• W3027832767 cites W2328721957 @default.
• W3027832767 cites W2399470175 @default.
• W3027832767 cites W2614118718 @default.
• W3027832767 cites W2736877353 @default.
• W3027832767 cites W2738922327 @default.
• W3027832767 cites W2751069763 @default.
• W3027832767 cites W2795352922 @default.
• W3027832767 cites W2889205385 @default.
• W3027832767 cites W2947340254 @default.
• W3027832767 cites W2958369641 @default.
• W3027832767 cites W2980539172 @default.
• W3027832767 cites W2981062789 @default.
• W3027832767 cites W2999474530 @default.
• W3027832767 cites W4241236756 @default.
• W3027832767 cites W4242301658 @default.
• W3027832767 doi "https://doi.org/10.1113/jp279694" @default.
• W3027832767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32445208" @default.
• W3027832767 hasPublicationYear "2020" @default.
• W3027832767 type Work @default.
• W3027832767 sameAs 3027832767 @default.
• W3027832767 citedByCount "21" @default.
• W3027832767 countsByYear W30278327672020 @default.
• W3027832767 countsByYear W30278327672021 @default.
• W3027832767 countsByYear W30278327672022 @default.
• W3027832767 countsByYear W30278327672023 @default.
• W3027832767 crossrefType "journal-article" @default.
• W3027832767 hasAuthorship W3027832767A5000775806 @default.
• W3027832767 hasAuthorship W3027832767A5002422164 @default.
• W3027832767 hasAuthorship W3027832767A5007696105 @default.
• W3027832767 hasAuthorship W3027832767A5009949348 @default.
• W3027832767 hasAuthorship W3027832767A5019289302 @default.
• W3027832767 hasAuthorship W3027832767A5020573984 @default.
• W3027832767 hasAuthorship W3027832767A5033827870 @default.
• W3027832767 hasAuthorship W3027832767A5035845233 @default.
• W3027832767 hasAuthorship W3027832767A5061653786 @default.
• W3027832767 hasAuthorship W3027832767A5074850666 @default.
• W3027832767 hasAuthorship W3027832767A5080646983 @default.
• W3027832767 hasAuthorship W3027832767A5082755711 @default.
• W3027832767 hasAuthorship W3027832767A5086806040 @default.
• W3027832767 hasBestOaLocation W30278327671 @default.
• W3027832767 hasConcept C105702510 @default.
• W3027832767 hasConcept C126322002 @default.
• W3027832767 hasConcept C127172972 @default.
• W3027832767 hasConcept C140793950 @default.
• W3027832767 hasConcept C144024400 @default.
• W3027832767 hasConcept C149923435 @default.
• W3027832767 hasConcept C159985019 @default.
• W3027832767 hasConcept C192562407 @default.
• W3027832767 hasConcept C2524010 @default.
• W3027832767 hasConcept C2776185378 @default.
• W3027832767 hasConcept C2776557347 @default.
• W3027832767 hasConcept C2778039513 @default.
• W3027832767 hasConcept C2780959883 @default.
• W3027832767 hasConcept C2994203641 @default.
• W3027832767 hasConcept C33923547 @default.

• next