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- W3027863088 abstract "Significance CD8 + T lymphocytes protect from intracellular pathogens by recognizing pathogen's antigenic peptides presented on MHC-I molecules. Many viruses evade T cell control by using genes that subvert MHC-I presentation on infected cells. Here we shift this paradigm and show that viral proteins that block the effector branch of T cells are more efficient for T cell evasion than MHC-I downregulation. The block of signaling in infected target cells at the level of caspase-8 as a crucial convergence point of death-receptor and perforine/granzyme pathways in the viral evasion of cytotoxic T cells. We show that these principles apply in the clinically relevant HCMV infection and in the biologically relevant in vivo context, using the MCMV experimental model." @default.
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- W3027863088 date "2020-05-22" @default.
- W3027863088 modified "2023-10-10" @default.
- W3027863088 title "Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells" @default.
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- W3027863088 doi "https://doi.org/10.1073/pnas.1914667117" @default.
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