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- W3027868414 abstract "The rapid-acting antidepressant and antisuicidal effects of the anesthetic ( R , S )-ketamine, an N -methyl-d-aspartate receptor (NMDAR) antagonist, is an important discovery in depression research (1). However, the precise molecular mechanisms underlying ( R , S )-ketamine’s antidepressant actions remain unknown. Naltrexone, an opioid receptor antagonist, blocked the rapid antidepressant and antisuicidal effects of ( R , S )-ketamine in treatment-resistant patients with depression (2, 3). Although the sample size was small ( n = 7), the authors concluded that opioid receptor activation is required for the observed ( R , S )-ketamine effects. In contrast, some reports suggest that depressed patients who experience antidepressant effects of ( R , S )-ketamine lack opioid systems (4, 5 … [↵][1]1Email: hashimoto{at}faculty.chiba-u.jp. [1]: #xref-corresp-1-1" @default.
- W3027868414 created "2020-05-29" @default.
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- W3027868414 date "2020-05-19" @default.
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- W3027868414 title "Are NMDA and opioid receptors involved in the antidepressant actions of ketamine?" @default.
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- W3027868414 doi "https://doi.org/10.1073/pnas.2001264117" @default.
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