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- W3027895384 endingPage "104949" @default.
- W3027895384 startingPage "104949" @default.
- W3027895384 abstract "Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and function and potential strategies to mitigate adverse consequences of SE. An acute 2 h episode of FSE was induced in anesthetized mice by epidural application of gabazine +4-aminopyridine over sensorimotor neocortex. Ten and 30 days later, the morphological and functional consequences of this single episode of FSE were studied using immunocytochemical and electrophysiological techniques. Results, focused on cortical layer V, showed astrogliosis, microgliosis, decreased neuronal density, and increased excitatory synapses, along with increased immunoreactivity for thrombospondin 2 (TSP2) and α2δ-1 proteins. In addition, neocortical slices, obtained from the area of prior focal seizure activity, showed abnormal epileptiform burst discharges along with increases in the frequency of miniature and spontaneous excitatory postsynaptic currents in layer V pyramidal cells, together with decreases in both parvalbumin immunoreactivity (PV-IR) and the frequency of miniature inhibitory postsynaptic currents in layer V pyramidal cells. Treatment with an approved drug, gabapentin (GBP) (ip 100 mg/kg/day 3×/day for 7 days following the FSE episode), prevented the gliosis, the enhanced TSP2- and α2δ-1- IR and the increased excitatory synaptic density in the affected neocortex. This model provides an approach for assessing adverse effects of FSE on neocortical structure and function and potential prophylactic treatments." @default.
- W3027895384 created "2020-05-29" @default.
- W3027895384 creator A5078296198 @default.
- W3027895384 creator A5082416156 @default.
- W3027895384 creator A5082613410 @default.
- W3027895384 date "2020-08-01" @default.
- W3027895384 modified "2023-09-26" @default.
- W3027895384 title "Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury" @default.
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- W3027895384 doi "https://doi.org/10.1016/j.nbd.2020.104949" @default.
- W3027895384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8083016" @default.
- W3027895384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32442680" @default.
- W3027895384 hasPublicationYear "2020" @default.
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