FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3027931358> ?p ?o ?g. }

• W3027931358 endingPage "2404" @default.
• W3027931358 startingPage "2395" @default.
• W3027931358 abstract "Menthol is a widely used tobacco constituent that has shown to enhance nicotine’s reinforcing effects. To determine whether injected menthol also alters nicotine’s stimulus effects, we used a drug discrimination task. A total of 57 adult Sprague-Dawley rats (28M, 29F) received 20 positive and 20 negative days (intermixed) of discrimination training. On positive days, rats received a group-specific menthol and nicotine injection (VEH + 0.1 NIC, 1 M + 0.1 NIC, 5 M + 0.1 NIC, VEH + 0.4 NIC, 1 M + 0.4 NIC, 5 M + 0.4 NIC; mg/kg) before eight 15-s cue light presentations (conditioned stimulus (CS)), each followed by 4-s sucrose access. On negative days, all rats were injected with vehicle and saline before eight non-reinforced CS presentations. Next, rats underwent generalization testing with 30 dose combinations of menthol and nicotine. The change in drug-mediated anticipatory goal tracking during the CS was calculated as a difference score (CS minus pre-CS responding). All groups readily acquired drug discrimination. However, difference scores for the 5M + 0.1 NIC group were lower for females. Additionally, females had lower scores for 0.05, 0.1, and 0.4 mg/kg nicotine generalization tests. The lowest nicotine dose discriminable from saline was 0.05 mg/kg for females but 0.025 mg/kg for males. Co-administration with 5 or 10 mg/kg menthol weakened discrimination performance between 0.1 and 0.4 mg/kg and between 0.1 and 0.05 mg/kg nicotine for 0.1 mg/kg nicotine training groups. Female rats that were trained with 0.1 mg/kg nicotine were more sensitive to menthol’s modulatory effects on nicotine’s stimulus effects. This highlights the importance of taking sex and training dose into account when evaluating the interoceptive stimulus effects of nicotine and menthol." @default.
• W3027931358 created "2020-05-29" @default.
• W3027931358 creator A5022994610 @default.
• W3027931358 creator A5023659068 @default.
• W3027931358 creator A5046531443 @default.
• W3027931358 creator A5047808107 @default.
• W3027931358 creator A5051604129 @default.
• W3027931358 creator A5056711950 @default.
• W3027931358 date "2020-05-24" @default.
• W3027931358 modified "2023-10-14" @default.
• W3027931358 title "Menthol blunts the interoceptive discriminative stimulus effects of nicotine in female but not male rats" @default.
• W3027931358 cites W1484501214 @default.
• W3027931358 cites W1968431644 @default.
• W3027931358 cites W1979658282 @default.
• W3027931358 cites W2028615921 @default.
• W3027931358 cites W2038699277 @default.
• W3027931358 cites W2039845572 @default.
• W3027931358 cites W2048595857 @default.
• W3027931358 cites W2083134014 @default.
• W3027931358 cites W2084004979 @default.
• W3027931358 cites W2084302047 @default.
• W3027931358 cites W2088402353 @default.
• W3027931358 cites W2114694355 @default.
• W3027931358 cites W2117878982 @default.
• W3027931358 cites W2121893408 @default.
• W3027931358 cites W2124581501 @default.
• W3027931358 cites W2138013438 @default.
• W3027931358 cites W2142542079 @default.
• W3027931358 cites W2144893829 @default.
• W3027931358 cites W2145049556 @default.
• W3027931358 cites W2148887789 @default.
• W3027931358 cites W2217221412 @default.
• W3027931358 cites W2239614844 @default.
• W3027931358 cites W2288169681 @default.
• W3027931358 cites W2294853125 @default.
• W3027931358 cites W2316558508 @default.
• W3027931358 cites W2318802957 @default.
• W3027931358 cites W2335726630 @default.
• W3027931358 cites W2500829331 @default.
• W3027931358 cites W2518165853 @default.
• W3027931358 cites W2528881274 @default.
• W3027931358 cites W2534004297 @default.
• W3027931358 cites W2587937590 @default.
• W3027931358 cites W2606092197 @default.
• W3027931358 cites W2620958385 @default.
• W3027931358 cites W2742055610 @default.
• W3027931358 cites W2752829144 @default.
• W3027931358 cites W2756296492 @default.
• W3027931358 cites W2759322316 @default.
• W3027931358 cites W2766693460 @default.
• W3027931358 cites W2891165841 @default.
• W3027931358 cites W2902831728 @default.
• W3027931358 cites W2944208798 @default.
• W3027931358 cites W4234676034 @default.
• W3027931358 cites W4242289937 @default.
• W3027931358 doi "https://doi.org/10.1007/s00213-020-05542-8" @default.
• W3027931358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7354904" @default.
• W3027931358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32448943" @default.
• W3027931358 hasPublicationYear "2020" @default.
• W3027931358 type Work @default.
• W3027931358 sameAs 3027931358 @default.
• W3027931358 citedByCount "6" @default.
• W3027931358 countsByYear W30279313582020 @default.
• W3027931358 countsByYear W30279313582021 @default.
• W3027931358 countsByYear W30279313582022 @default.
• W3027931358 crossrefType "journal-article" @default.
• W3027931358 hasAuthorship W3027931358A5022994610 @default.
• W3027931358 hasAuthorship W3027931358A5023659068 @default.
• W3027931358 hasAuthorship W3027931358A5046531443 @default.
• W3027931358 hasAuthorship W3027931358A5047808107 @default.
• W3027931358 hasAuthorship W3027931358A5051604129 @default.
• W3027931358 hasAuthorship W3027931358A5056711950 @default.
• W3027931358 hasBestOaLocation W30279313582 @default.
• W3027931358 hasConcept C126322002 @default.
• W3027931358 hasConcept C15744967 @default.
• W3027931358 hasConcept C178790620 @default.
• W3027931358 hasConcept C185592680 @default.
• W3027931358 hasConcept C2777397205 @default.
• W3027931358 hasConcept C2779547902 @default.
• W3027931358 hasConcept C2779918689 @default.
• W3027931358 hasConcept C2780194911 @default.
• W3027931358 hasConcept C42219234 @default.
• W3027931358 hasConcept C542102704 @default.
• W3027931358 hasConcept C57022672 @default.
• W3027931358 hasConcept C71924100 @default.
• W3027931358 hasConcept C98274493 @default.
• W3027931358 hasConceptScore W3027931358C126322002 @default.
• W3027931358 hasConceptScore W3027931358C15744967 @default.
• W3027931358 hasConceptScore W3027931358C178790620 @default.
• W3027931358 hasConceptScore W3027931358C185592680 @default.
• W3027931358 hasConceptScore W3027931358C2777397205 @default.
• W3027931358 hasConceptScore W3027931358C2779547902 @default.
• W3027931358 hasConceptScore W3027931358C2779918689 @default.
• W3027931358 hasConceptScore W3027931358C2780194911 @default.
• W3027931358 hasConceptScore W3027931358C42219234 @default.
• W3027931358 hasConceptScore W3027931358C542102704 @default.
• W3027931358 hasConceptScore W3027931358C57022672 @default.
• W3027931358 hasConceptScore W3027931358C71924100 @default.

• next