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- W3027970966 abstract "We thank Drs. Carcel et al.1 for helping advance our understanding of sex differences in stroke treatment and outcome. The accompanying editorial astutely suggested that the greater poststroke disability seen among the women in this study may reflect a survivor bias effect.2 However, we would also like to highlight the sex difference in premorbid disability per the modified-Rankin Scale (mRS) that was evident in the ENCHANTED, SCAST, and HeadPoST trials (unavailable for INTERACT) in table 2. Men were more likely to have premorbid mRS of 0 (no symptoms). Sex differences in premorbid mRS may account for apparent differences in stroke outcomes between men and women.3 It would be interesting to further validate the disability analysis using ordinal rather than dichotomous analysis of the mRS (allowing more premorbidly disabled patients to contribute to treatment effect)4 or by comparing the difference between poststroke and prestroke mRS (“delta-mRS”) in men and women, which has predictive validity for long-term poststroke outcomes.5 Alternatively, if numbers permit, perhaps the dichotomous mRS analysis could be stratified by premorbid disability (e.g., premorbid mRS = 0 together, mRS = 1 together, and so forth) to see if the difference remains." @default.
- W3027970966 created "2020-05-29" @default.
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- W3027970966 date "2020-11-23" @default.
- W3027970966 modified "2023-09-25" @default.
- W3027970966 title "Reader response: Sex differences in treatment and outcome after stroke: Pooled analysis including 19,000 participants" @default.
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- W3027970966 doi "https://doi.org/10.1212/wnl.0000000000011041" @default.
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