FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028010767> ?p ?o ?g. }

• W3028010767 endingPage "1752" @default.
• W3028010767 startingPage "1742" @default.
• W3028010767 abstract "Abstract Aim To investigate the effects of liraglutide treatment on glycaemic control and adipose tissue metabolism in overweight and obese people with type 1 diabetes (T1DM). Research design and methods A total of 84 adult overweight and obese patients with T1DM, with no detectable C‐peptide, were randomized (1:1) to either placebo or 1.8 mg/d liraglutide for 6 months. Blood samples were collected at 0, 12 and 26 weeks. Subcutaneous adipose tissue biopsies, a high‐calorie high‐fat meal challenge test, continuous glucose monitoring, dual‐energy X‐ray absorptiometry and MRI were performed before and at the end of treatment. Results In all, 37 and 27 patients who received liraglutide and placebo, respectively, completed the study. Glycated haemoglobin fell by 0.41 ± 0.18% (4.5±1.4 mmol/mol) from baseline after liraglutide treatment ( P = 0.001), and by 0.29 ± 0.19% (3.1±2.0 mmol/mol) compared to placebo ( P = 0.1). There was no increase in hypoglycaemia, while the time spent in normal glycaemia increased ( P = 0.015) and time spent in hyperglycaemia decreased ( P = 0.019). Body weight fell significantly in the liraglutide group, mostly in the form of fat mass loss (including visceral fat), with no change in lean mass. Systolic blood pressure (SBP) also fell after liraglutide treatment. Liraglutide also caused a significant increase in the expression of adipose tissue triglyceride lipase, carnitine palmitoyl transferase‐1, peroxisome proliferator‐activated receptor (PPAR)α, PPARδ, uncoupling protein‐2 and type 2 iodothyronine deiodinase in the adipose tissue. Conclusions Liraglutide improves glycaemia, reduces adiposity and SBP. Liraglutide also stimulates mechanisms involved with an increase in lipid oxidation and thermogenesis, while conserving lean body mass." @default.
• W3028010767 created "2020-05-29" @default.
• W3028010767 creator A5010209626 @default.
• W3028010767 creator A5021588467 @default.
• W3028010767 creator A5032877471 @default.
• W3028010767 creator A5037251074 @default.
• W3028010767 creator A5037611723 @default.
• W3028010767 creator A5045434563 @default.
• W3028010767 creator A5048936827 @default.
• W3028010767 creator A5079289558 @default.
• W3028010767 creator A5086608705 @default.
• W3028010767 creator A5087512032 @default.
• W3028010767 date "2020-07-08" @default.
• W3028010767 modified "2023-10-02" @default.
• W3028010767 title "Liraglutide treatment in overweight and obese patients with type 1 diabetes: A 26‐week randomized controlled trial; mechanisms of weight loss" @default.
• W3028010767 cites W1920410436 @default.
• W3028010767 cites W1981820664 @default.
• W3028010767 cites W1985442339 @default.
• W3028010767 cites W1986068446 @default.
• W3028010767 cites W2025995365 @default.
• W3028010767 cites W2043054174 @default.
• W3028010767 cites W2097080554 @default.
• W3028010767 cites W2104788765 @default.
• W3028010767 cites W2108365604 @default.
• W3028010767 cites W2123736006 @default.
• W3028010767 cites W2128939426 @default.
• W3028010767 cites W2143149722 @default.
• W3028010767 cites W2170075604 @default.
• W3028010767 cites W2337735601 @default.
• W3028010767 cites W2494601841 @default.
• W3028010767 cites W2512809703 @default.
• W3028010767 cites W2514658869 @default.
• W3028010767 cites W2600890226 @default.
• W3028010767 cites W2624031057 @default.
• W3028010767 cites W2754605776 @default.
• W3028010767 cites W2786101762 @default.
• W3028010767 cites W2793249329 @default.
• W3028010767 cites W2902094151 @default.
• W3028010767 cites W2905452451 @default.
• W3028010767 cites W2907961170 @default.
• W3028010767 doi "https://doi.org/10.1111/dom.14090" @default.
• W3028010767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32424935" @default.
• W3028010767 hasPublicationYear "2020" @default.
• W3028010767 type Work @default.
• W3028010767 sameAs 3028010767 @default.
• W3028010767 citedByCount "26" @default.
• W3028010767 countsByYear W30280107672021 @default.
• W3028010767 countsByYear W30280107672022 @default.
• W3028010767 countsByYear W30280107672023 @default.
• W3028010767 crossrefType "journal-article" @default.
• W3028010767 hasAuthorship W3028010767A5010209626 @default.
• W3028010767 hasAuthorship W3028010767A5021588467 @default.
• W3028010767 hasAuthorship W3028010767A5032877471 @default.
• W3028010767 hasAuthorship W3028010767A5037251074 @default.
• W3028010767 hasAuthorship W3028010767A5037611723 @default.
• W3028010767 hasAuthorship W3028010767A5045434563 @default.
• W3028010767 hasAuthorship W3028010767A5048936827 @default.
• W3028010767 hasAuthorship W3028010767A5079289558 @default.
• W3028010767 hasAuthorship W3028010767A5086608705 @default.
• W3028010767 hasAuthorship W3028010767A5087512032 @default.
• W3028010767 hasConcept C126322002 @default.
• W3028010767 hasConcept C134018914 @default.
• W3028010767 hasConcept C142724271 @default.
• W3028010767 hasConcept C171089720 @default.
• W3028010767 hasConcept C204787440 @default.
• W3028010767 hasConcept C27081682 @default.
• W3028010767 hasConcept C2777180221 @default.
• W3028010767 hasConcept C2780586474 @default.
• W3028010767 hasConcept C2781308992 @default.
• W3028010767 hasConcept C511355011 @default.
• W3028010767 hasConcept C544821477 @default.
• W3028010767 hasConcept C555293320 @default.
• W3028010767 hasConcept C71924100 @default.
• W3028010767 hasConceptScore W3028010767C126322002 @default.
• W3028010767 hasConceptScore W3028010767C134018914 @default.
• W3028010767 hasConceptScore W3028010767C142724271 @default.
• W3028010767 hasConceptScore W3028010767C171089720 @default.
• W3028010767 hasConceptScore W3028010767C204787440 @default.
• W3028010767 hasConceptScore W3028010767C27081682 @default.
• W3028010767 hasConceptScore W3028010767C2777180221 @default.
• W3028010767 hasConceptScore W3028010767C2780586474 @default.
• W3028010767 hasConceptScore W3028010767C2781308992 @default.
• W3028010767 hasConceptScore W3028010767C511355011 @default.
• W3028010767 hasConceptScore W3028010767C544821477 @default.
• W3028010767 hasConceptScore W3028010767C555293320 @default.
• W3028010767 hasConceptScore W3028010767C71924100 @default.
• W3028010767 hasIssue "10" @default.
• W3028010767 hasLocation W30280107671 @default.
• W3028010767 hasOpenAccess W3028010767 @default.
• W3028010767 hasPrimaryLocation W30280107671 @default.
• W3028010767 hasRelatedWork W1964688190 @default.
• W3028010767 hasRelatedWork W1978718098 @default.
• W3028010767 hasRelatedWork W2017606817 @default.
• W3028010767 hasRelatedWork W2027098794 @default.
• W3028010767 hasRelatedWork W2049045125 @default.
• W3028010767 hasRelatedWork W2071032213 @default.
• W3028010767 hasRelatedWork W2081564223 @default.
• W3028010767 hasRelatedWork W2167541966 @default.

• next