Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028060887> ?p ?o ?g. }
- W3028060887 endingPage "3683" @default.
- W3028060887 startingPage "3683" @default.
- W3028060887 abstract "Protein folding is a substantively error prone process, especially when it occurs in the endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory protein folding, recognizes aberrant folding states, and retrotranslocates permanently misfolded proteins from the ER back to the cytosol; these misfolded proteins are then degraded by the ubiquitin–proteasome system termed as the ER-associated degradation (ERAD). The 26S proteasome is a multisubunit protease complex that recognizes and degrades ubiquitinated proteins in an ATP-dependent manner. The complex structure of the 26S proteasome requires exquisite regulation at the transcription, translation, and molecular assembly levels. Nuclear factor erythroid-derived 2-related factor 1 (Nrf1; NFE2L1), an ER-resident transcription factor, has recently been shown to be responsible for the coordinated expression of all the proteasome subunit genes upon proteasome impairment in mammalian cells. In this review, we summarize the current knowledge regarding the transcriptional regulation of the proteasome, as well as recent findings concerning the regulation of Nrf1 transcription activity in ER homeostasis and metabolic processes." @default.
- W3028060887 created "2020-05-29" @default.
- W3028060887 creator A5018182534 @default.
- W3028060887 creator A5022317594 @default.
- W3028060887 date "2020-05-23" @default.
- W3028060887 modified "2023-10-18" @default.
- W3028060887 title "ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond" @default.
- W3028060887 cites W1013361806 @default.
- W3028060887 cites W1081615781 @default.
- W3028060887 cites W120703973 @default.
- W3028060887 cites W1590405048 @default.
- W3028060887 cites W1606812696 @default.
- W3028060887 cites W192390236 @default.
- W3028060887 cites W1967161878 @default.
- W3028060887 cites W1968045891 @default.
- W3028060887 cites W1969727475 @default.
- W3028060887 cites W1972432934 @default.
- W3028060887 cites W1975647625 @default.
- W3028060887 cites W1976582166 @default.
- W3028060887 cites W1983036561 @default.
- W3028060887 cites W1983392900 @default.
- W3028060887 cites W1989541636 @default.
- W3028060887 cites W1990699073 @default.
- W3028060887 cites W1991558827 @default.
- W3028060887 cites W1991930087 @default.
- W3028060887 cites W1996826558 @default.
- W3028060887 cites W2003384075 @default.
- W3028060887 cites W2007115735 @default.
- W3028060887 cites W2007143913 @default.
- W3028060887 cites W2009002231 @default.
- W3028060887 cites W2009966467 @default.
- W3028060887 cites W2012109738 @default.
- W3028060887 cites W2015583980 @default.
- W3028060887 cites W2017722997 @default.
- W3028060887 cites W2018970686 @default.
- W3028060887 cites W2019313414 @default.
- W3028060887 cites W2025341515 @default.
- W3028060887 cites W2025714022 @default.
- W3028060887 cites W2027721238 @default.
- W3028060887 cites W2030803511 @default.
- W3028060887 cites W2031333602 @default.
- W3028060887 cites W2036220628 @default.
- W3028060887 cites W2039866515 @default.
- W3028060887 cites W2040042255 @default.
- W3028060887 cites W2040434321 @default.
- W3028060887 cites W2041136562 @default.
- W3028060887 cites W2043619696 @default.
- W3028060887 cites W2047757567 @default.
- W3028060887 cites W2050072642 @default.
- W3028060887 cites W2051292368 @default.
- W3028060887 cites W2051641469 @default.
- W3028060887 cites W2054827827 @default.
- W3028060887 cites W2064919595 @default.
- W3028060887 cites W2065544945 @default.
- W3028060887 cites W2065990069 @default.
- W3028060887 cites W2066742532 @default.
- W3028060887 cites W2066781103 @default.
- W3028060887 cites W2067633065 @default.
- W3028060887 cites W2068408381 @default.
- W3028060887 cites W2069530486 @default.
- W3028060887 cites W2070367241 @default.
- W3028060887 cites W2071995179 @default.
- W3028060887 cites W2075571292 @default.
- W3028060887 cites W2075939049 @default.
- W3028060887 cites W2080100550 @default.
- W3028060887 cites W2083089496 @default.
- W3028060887 cites W2089761608 @default.
- W3028060887 cites W2090294867 @default.
- W3028060887 cites W2092159694 @default.
- W3028060887 cites W2092921819 @default.
- W3028060887 cites W2094371012 @default.
- W3028060887 cites W2096275228 @default.
- W3028060887 cites W2098567793 @default.
- W3028060887 cites W2102436900 @default.
- W3028060887 cites W2102839649 @default.
- W3028060887 cites W2112436307 @default.
- W3028060887 cites W2112660386 @default.
- W3028060887 cites W2112788285 @default.
- W3028060887 cites W2118394016 @default.
- W3028060887 cites W2118937204 @default.
- W3028060887 cites W2119544175 @default.
- W3028060887 cites W2135646750 @default.
- W3028060887 cites W2137151552 @default.
- W3028060887 cites W2137331540 @default.
- W3028060887 cites W2140508494 @default.
- W3028060887 cites W2143662151 @default.
- W3028060887 cites W2145281326 @default.
- W3028060887 cites W2148242921 @default.
- W3028060887 cites W2151274004 @default.
- W3028060887 cites W2151762765 @default.
- W3028060887 cites W2154082117 @default.
- W3028060887 cites W2154683743 @default.
- W3028060887 cites W2156322705 @default.
- W3028060887 cites W2158982890 @default.
- W3028060887 cites W2159728029 @default.
- W3028060887 cites W2160395555 @default.
- W3028060887 cites W2162884522 @default.
- W3028060887 cites W2163292409 @default.