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- W3028065870 endingPage "110224" @default.
- W3028065870 startingPage "110224" @default.
- W3028065870 abstract "Chinese herb Rhubarb (Dahuang), one of the most widely used traditional Chinese medicine in clinical application for over a thousand years and known as the “General (Jiang Jun)” in Chinese medical herb, currently used clinically for long-term treatment of gastrointestinal diseases and chronic liver diseases. Through previous researches, it has been identified that Rhubarb possessed a good hepatoprotective effect, which primarily protected liver from oxidation, fibrosis and cirrhosis, liver failure, hepatocellular carcinoma and various types of hepatitis. Meanwhile, it has been recently reported that long-term administration of Rhubarb preparation may undertake the risk of liver damage, which has aroused worldwide doubts about the safety of Rhubarb. Therefore, how to correctly understand the two-way effect of Rhubarb on liver protection and liver toxicity provides a basis for scientific evaluation of Rhubarb's efficacy on liver and side effects, as well as guiding clinical rational drug use. In this review, the mechanisms of Rhubarb how to play a role in hepatoprotection and why it causes hepatotoxic potential will be elaborated in detail and critically. In addition, some positive clinical guidances are also advised on how to reduce its hepatotoxicity in medical treatment." @default.
- W3028065870 created "2020-05-29" @default.
- W3028065870 creator A5013569757 @default.
- W3028065870 creator A5014561217 @default.
- W3028065870 creator A5018593334 @default.
- W3028065870 creator A5041499448 @default.
- W3028065870 creator A5065468740 @default.
- W3028065870 creator A5079985407 @default.
- W3028065870 date "2020-07-01" @default.
- W3028065870 modified "2023-10-10" @default.
- W3028065870 title "Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the “General (Jiang Jun)” in Chinese medical herb" @default.
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