FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028067123> ?p ?o ?g. }

• W3028067123 abstract "ABSTRACT Background The SARS-CoV-2 outbreak urgently requires sensitive and convenient COVID-19 diagnostics for the containment and timely treatment of patients. We aimed to develop and validate a novel reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect SARS-CoV-2 in qualified laboratories and point-of-care settings. Methods Patients with suspected COVID-19 and close contacts were recruited from two hospitals between Jan 26 and April 8, 2020. Respiratory samples were collected and tested using the RT-LAMP assays, and the results were compared with those obtained by RT-qPCR. Samples yielding inconsistent results between these two methods were subjected to next-generation sequencing for confirmation. The RT-LAMP assay was also tested on an asymptomatic COVID-19 carrier and patients with other respiratory viral infections. Results Samples were collected from a cohort of 129 cases (329 nasopharyngeal swabs) and an independent cohort of 76 patients (152 nasopharyngeal swabs and sputum samples). The RT-LAMP assay was validated to be accurate (overall sensitivity and specificity: 88.89% and 99.00%; positive and negative predictive values: 94.74% and 97.78%, respectively) and diagnostically useful (positive and negative likelihood ratios: 88.89 and 0.11, respectively). RT-LAMP showed an increased sensitivity (88.89% vs 81.48%) and high consistency (kappa 0.92) compared with RT-qPCR for SARS-CoV-2 screening while requiring only constant temperature heating and visual inspection. The time required for RT-LAMP was less than 1 h from sample preparation to result. In addition, RT-LAMP was feasible for use with asymptomatic patients and did not cross-react with other respiratory pathogens. Conclusion The developed RT-LAMP assay offers rapid, sensitive and straightforward detection of SARS-CoV-2 infection and could aid the expansion of COVID-19 testing in the public domain and hospitals." @default.
• W3028067123 created "2020-05-29" @default.
• W3028067123 creator A5003153613 @default.
• W3028067123 creator A5004366207 @default.
• W3028067123 creator A5005390653 @default.
• W3028067123 creator A5009088280 @default.
• W3028067123 creator A5016258395 @default.
• W3028067123 creator A5021181080 @default.
• W3028067123 creator A5022893982 @default.
• W3028067123 creator A5037332893 @default.
• W3028067123 creator A5048988662 @default.
• W3028067123 creator A5056136261 @default.
• W3028067123 creator A5067274947 @default.
• W3028067123 creator A5071469153 @default.
• W3028067123 creator A5071798264 @default.
• W3028067123 creator A5080562842 @default.
• W3028067123 creator A5090963178 @default.
• W3028067123 date "2020-05-23" @default.
• W3028067123 modified "2023-10-01" @default.
• W3028067123 title "Development and clinical application of a rapid and sensitive loop-mediated isothermal amplification test for SARS-CoV-2 infection" @default.
• W3028067123 cites W1984966664 @default.
• W3028067123 cites W2003740803 @default.
• W3028067123 cites W2092394444 @default.
• W3028067123 cites W2101258647 @default.
• W3028067123 cites W2105275554 @default.
• W3028067123 cites W2140171660 @default.
• W3028067123 cites W2152937580 @default.
• W3028067123 cites W2611308758 @default.
• W3028067123 cites W2617274523 @default.
• W3028067123 cites W2782968899 @default.
• W3028067123 cites W2921301002 @default.
• W3028067123 cites W3004318991 @default.
• W3028067123 cites W3006961006 @default.
• W3028067123 cites W3008028633 @default.
• W3028067123 cites W3008116551 @default.
• W3028067123 cites W3008452791 @default.
• W3028067123 cites W3008962515 @default.
• W3028067123 cites W3010595167 @default.
• W3028067123 cites W3010603941 @default.
• W3028067123 cites W3012190524 @default.
• W3028067123 cites W3013893137 @default.
• W3028067123 cites W3013985547 @default.
• W3028067123 cites W3017152347 @default.
• W3028067123 cites W3017669300 @default.
• W3028067123 cites W4206798761 @default.
• W3028067123 doi "https://doi.org/10.1101/2020.05.20.20108530" @default.
• W3028067123 hasPublicationYear "2020" @default.
• W3028067123 type Work @default.
• W3028067123 sameAs 3028067123 @default.
• W3028067123 citedByCount "4" @default.
• W3028067123 countsByYear W30280671232020 @default.
• W3028067123 countsByYear W30280671232021 @default.
• W3028067123 crossrefType "posted-content" @default.
• W3028067123 hasAuthorship W3028067123A5003153613 @default.
• W3028067123 hasAuthorship W3028067123A5004366207 @default.
• W3028067123 hasAuthorship W3028067123A5005390653 @default.
• W3028067123 hasAuthorship W3028067123A5009088280 @default.
• W3028067123 hasAuthorship W3028067123A5016258395 @default.
• W3028067123 hasAuthorship W3028067123A5021181080 @default.
• W3028067123 hasAuthorship W3028067123A5022893982 @default.
• W3028067123 hasAuthorship W3028067123A5037332893 @default.
• W3028067123 hasAuthorship W3028067123A5048988662 @default.
• W3028067123 hasAuthorship W3028067123A5056136261 @default.
• W3028067123 hasAuthorship W3028067123A5067274947 @default.
• W3028067123 hasAuthorship W3028067123A5071469153 @default.
• W3028067123 hasAuthorship W3028067123A5071798264 @default.
• W3028067123 hasAuthorship W3028067123A5080562842 @default.
• W3028067123 hasAuthorship W3028067123A5090963178 @default.
• W3028067123 hasBestOaLocation W30280671231 @default.
• W3028067123 hasConcept C126322002 @default.
• W3028067123 hasConcept C137916694 @default.
• W3028067123 hasConcept C142724271 @default.
• W3028067123 hasConcept C159047783 @default.
• W3028067123 hasConcept C203014093 @default.
• W3028067123 hasConcept C2776301714 @default.
• W3028067123 hasConcept C2777910003 @default.
• W3028067123 hasConcept C2779134260 @default.
• W3028067123 hasConcept C2781069245 @default.
• W3028067123 hasConcept C3007834351 @default.
• W3028067123 hasConcept C3008058167 @default.
• W3028067123 hasConcept C3019719930 @default.
• W3028067123 hasConcept C524204448 @default.
• W3028067123 hasConcept C534529494 @default.
• W3028067123 hasConcept C53789813 @default.
• W3028067123 hasConcept C54355233 @default.
• W3028067123 hasConcept C552990157 @default.
• W3028067123 hasConcept C60635243 @default.
• W3028067123 hasConcept C64841741 @default.
• W3028067123 hasConcept C71924100 @default.
• W3028067123 hasConcept C72563966 @default.
• W3028067123 hasConcept C86803240 @default.
• W3028067123 hasConceptScore W3028067123C126322002 @default.
• W3028067123 hasConceptScore W3028067123C137916694 @default.
• W3028067123 hasConceptScore W3028067123C142724271 @default.
• W3028067123 hasConceptScore W3028067123C159047783 @default.
• W3028067123 hasConceptScore W3028067123C203014093 @default.
• W3028067123 hasConceptScore W3028067123C2776301714 @default.
• W3028067123 hasConceptScore W3028067123C2777910003 @default.
• W3028067123 hasConceptScore W3028067123C2779134260 @default.
• W3028067123 hasConceptScore W3028067123C2781069245 @default.

• next