FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028285225> ?p ?o ?g. }

• W3028285225 endingPage "S104" @default.
• W3028285225 startingPage "S103" @default.
• W3028285225 abstract "Abstract Background Psychotic experiences (PE) include subliminal hallucinations and delusions without the characteristic functional impairment that constitutes a psychotic disorder. PE are prevalent during childhood and adolescence and studies show a clear link with higher risk to clinical psychosis and schizophrenia. The persistence and accumulation of psychosocial problems are also well established risk factors, but how they interplay with genetic risk is still unclear, especially during developmental stages. Polygenic risk score to schizophrenia (PRS-SZ) and the polyenviromic risk score (PERS) are two validated measures created to assess the contribution of each factor on the development of such psychopathology. Our aim was to verify if PRS and PERS jointly are able to predict psychotic experiences in a cohort of children and adolescents, considering two time-points. Methods We analyzed data from the High Risk Cohort (HRC) for Psychiatric Disorders, composed of 2511 children and adolescents from São Paulo and Porto Alegre. PRS-SZ was calculated using summary statistics from the PGC and corrected for the ten first principal components (PC) of the GWAS. In order to calculate the PERS, we used data corresponding to the nine variables that are consider on the score, being respectively, winter or spring birth, urbanicity, cannabis use, advanced paternal age, obstetric and perinatal complications, physical and sexual abuse, neglect and paternal death, therefore if the person is exposed to one or more enviromic factor the odds ratio corresponding to that factor are added up and divided by all factors considered on the calculation, generating the final score. PE was assessed through the Community Assessment of Psychotic Experiences (CAPE) and a latent variable was generated through confirmatory factor analysis producing a good model fit. The prediction model was performed using different linear regressions where the clinical outcome was the CAPE score and PRS and PERS as independent variables. We performed Spearman’s correlations in order to observe possible correlation between our variables. Results Our sample varied from 9 to 18 years old (Mean: 13.49, SD: 1.9, 53.9% male) and a total of 1704 individuals provided available CAPE scores, PRS and PERS. When Spearman’s correlations were performed, we observed a non-significant weak positive correlation between PERS x CAPE (R2 = 0.0118, p = 0.623) and between PRS x CAPE (R2 = 0.0292, p = 0.228) and a non-significant negative correlation between PERS x PRS (R2 = -0.03051, p = 0.207). Lastly, we perform a multiple linear regression and used in the model the ten first PC as covariables and, we observed that with an increase in one unit in the PRS, the model explain positively about 8% of the PE variance (R2 = 0.007986 (F(12;1691) = 2.143, p = 0.01225). When we used the PRS already adjusted by ten first PC in the model, this significance is lost (R2=0.0008381 F(2);1701, p=0.1804 (PC2 and PC8 explaining the most of variance). Discussion Previous studies have shown a lack of significant association between PRS-SZ and PE for youth samples. Our results are in line with such results, but also depict a trend direction for those variables. Although all correlations were non-significant statically, they show us their direction as discussed below. The higher PERS, higher the psychotic experience, suggesting known environment risk factors for psychosis play a role in the report of PE as well. The higher PRS, the higher psychotic experience also. On the other hand, we found a negative correlation between PERS and PRS. In addition, PERS and PRS jointly were not able to predict psychotic experience. Although non-significant, our results may shed light on knowledge of disease." @default.
• W3028285225 created "2020-05-29" @default.
• W3028285225 creator A5010820665 @default.
• W3028285225 creator A5027956781 @default.
• W3028285225 creator A5031579202 @default.
• W3028285225 creator A5031999460 @default.
• W3028285225 creator A5038221297 @default.
• W3028285225 creator A5069624680 @default.
• W3028285225 creator A5071370811 @default.
• W3028285225 creator A5081930990 @default.
• W3028285225 creator A5091625399 @default.
• W3028285225 date "2020-04-01" @default.
• W3028285225 modified "2023-10-12" @default.
• W3028285225 title "S174. POLYENVIRONMENTAL AND POLYGENIC RISK SCORES AND THE EMERGENCE OF PSYCHOTIC EXPERIENCES IN CHILDREN AND ADOLESCENTS" @default.
• W3028285225 doi "https://doi.org/10.1093/schbul/sbaa031.240" @default.
• W3028285225 hasPublicationYear "2020" @default.
• W3028285225 type Work @default.
• W3028285225 sameAs 3028285225 @default.
• W3028285225 citedByCount "1" @default.
• W3028285225 countsByYear W30282852252021 @default.
• W3028285225 crossrefType "journal-article" @default.
• W3028285225 hasAuthorship W3028285225A5010820665 @default.
• W3028285225 hasAuthorship W3028285225A5027956781 @default.
• W3028285225 hasAuthorship W3028285225A5031579202 @default.
• W3028285225 hasAuthorship W3028285225A5031999460 @default.
• W3028285225 hasAuthorship W3028285225A5038221297 @default.
• W3028285225 hasAuthorship W3028285225A5069624680 @default.
• W3028285225 hasAuthorship W3028285225A5071370811 @default.
• W3028285225 hasAuthorship W3028285225A5081930990 @default.
• W3028285225 hasAuthorship W3028285225A5091625399 @default.
• W3028285225 hasBestOaLocation W30282852251 @default.
• W3028285225 hasConcept C118552586 @default.
• W3028285225 hasConcept C123273963 @default.
• W3028285225 hasConcept C126322002 @default.
• W3028285225 hasConcept C150966472 @default.
• W3028285225 hasConcept C15744967 @default.
• W3028285225 hasConcept C2776289891 @default.
• W3028285225 hasConcept C2776412080 @default.
• W3028285225 hasConcept C2779727114 @default.
• W3028285225 hasConcept C50440223 @default.
• W3028285225 hasConcept C70410870 @default.
• W3028285225 hasConcept C71924100 @default.
• W3028285225 hasConcept C72563966 @default.
• W3028285225 hasConceptScore W3028285225C118552586 @default.
• W3028285225 hasConceptScore W3028285225C123273963 @default.
• W3028285225 hasConceptScore W3028285225C126322002 @default.
• W3028285225 hasConceptScore W3028285225C150966472 @default.
• W3028285225 hasConceptScore W3028285225C15744967 @default.
• W3028285225 hasConceptScore W3028285225C2776289891 @default.
• W3028285225 hasConceptScore W3028285225C2776412080 @default.
• W3028285225 hasConceptScore W3028285225C2779727114 @default.
• W3028285225 hasConceptScore W3028285225C50440223 @default.
• W3028285225 hasConceptScore W3028285225C70410870 @default.
• W3028285225 hasConceptScore W3028285225C71924100 @default.
• W3028285225 hasConceptScore W3028285225C72563966 @default.
• W3028285225 hasIssue "Supplement_1" @default.
• W3028285225 hasLocation W30282852251 @default.
• W3028285225 hasLocation W30282852252 @default.
• W3028285225 hasOpenAccess W3028285225 @default.
• W3028285225 hasPrimaryLocation W30282852251 @default.
• W3028285225 hasRelatedWork W2021447765 @default.
• W3028285225 hasRelatedWork W2053235457 @default.
• W3028285225 hasRelatedWork W2078687305 @default.
• W3028285225 hasRelatedWork W2090391053 @default.
• W3028285225 hasRelatedWork W2105939460 @default.
• W3028285225 hasRelatedWork W2135419962 @default.
• W3028285225 hasRelatedWork W2404925631 @default.
• W3028285225 hasRelatedWork W2409773826 @default.
• W3028285225 hasRelatedWork W2531053899 @default.
• W3028285225 hasRelatedWork W3031780556 @default.
• W3028285225 hasVolume "46" @default.
• W3028285225 isParatext "false" @default.
• W3028285225 isRetracted "false" @default.
• W3028285225 magId "3028285225" @default.
• W3028285225 workType "article" @default.