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• W3028287471 endingPage "45" @default.
• W3028287471 startingPage "36" @default.
• W3028287471 abstract "Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as “canonical” CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer." @default.
• W3028287471 created "2020-05-29" @default.
• W3028287471 creator A5032908029 @default.
• W3028287471 creator A5047451387 @default.
• W3028287471 date "2020-11-01" @default.
• W3028287471 modified "2023-10-02" @default.
• W3028287471 title "Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression" @default.
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