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- W3028294501 endingPage "116443" @default.
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- W3028294501 abstract "Heparin-like substances (HLS) have been described in various clinical situations, including in settings of liver disease associated with infection, transplant, and metastasis. HLS are generally attributed to circulating glycosaminoglycans. Initial results for this patient showed coagulopathy due to liver disease without HLS. Two weeks after liver transplantation, a 10 year-old female with liver failure patient began to bleed from catheter insertion sites, mouth, and nares and HLS was suspected. The patient subsequently died and these clinical samples resulted in the isolation of a single heparan sulfate (HS) present at high concentrations in the plasma. Analysis of this HS showed it had an intermediate between heparin and HS with low antithrombin-mediated anticoagulant activity. We speculate that this 10-year old patient might have a platelet function defect influenced by this unusual HS. Endothelial defects not measurable by our methods might have also contributed to the observed bleeding complications." @default.
- W3028294501 created "2020-05-29" @default.
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- W3028294501 date "2020-09-01" @default.
- W3028294501 modified "2023-09-24" @default.
- W3028294501 title "Structural characterization of a clinically described heparin-like substance in plasma causing bleeding" @default.
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- W3028294501 doi "https://doi.org/10.1016/j.carbpol.2020.116443" @default.
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