Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028327162> ?p ?o ?g. }
- W3028327162 endingPage "437" @default.
- W3028327162 startingPage "431" @default.
- W3028327162 abstract "The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage. Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via the circulating concentrations of metabolic hormones and nutrients, and then coordinate energy intake and expenditure to maintain energy homeostasis. Malfunction or loss of hypothalamic ARH neurons results in obesity. Accumulated evidence suggests that hypothalamic inflammation is a key pathological mechanism that links chronic overconsumption of a high-fat diet (HFD) with the development of obesity and related metabolic complications. Interestingly, overnutrition-induced hypothalamic inflammation occurs specifically in the ARH, where microglia initiate an inflammatory response by releasing proinflammatory cytokines and chemokines in response to excessive fatty acid flux. Upon more prolonged HFD consumption, astrocytes and perivascular macrophages become involved and sustain hypothalamic inflammation. ARH neurons are victims of hypothalamic inflammation, but they may actively participate in hypothalamic inflammation by sending quiescence or stress signals to surrounding glia. In this mini-review, we describe the current state of knowledge regarding the contributions of neurons and glia, and their interactions, to HFD-induced hypothalamic inflammation." @default.
- W3028327162 created "2020-05-29" @default.
- W3028327162 creator A5012866137 @default.
- W3028327162 creator A5031104910 @default.
- W3028327162 creator A5032268144 @default.
- W3028327162 creator A5036363002 @default.
- W3028327162 date "2020-05-31" @default.
- W3028327162 modified "2023-09-24" @default.
- W3028327162 title "Cellular Contributors to Hypothalamic Inflammation in Obesity." @default.
- W3028327162 cites W1511961767 @default.
- W3028327162 cites W1802404595 @default.
- W3028327162 cites W1964562779 @default.
- W3028327162 cites W1978916589 @default.
- W3028327162 cites W2000976612 @default.
- W3028327162 cites W2012630942 @default.
- W3028327162 cites W2012707242 @default.
- W3028327162 cites W2012730798 @default.
- W3028327162 cites W2015541518 @default.
- W3028327162 cites W2025131475 @default.
- W3028327162 cites W2028798690 @default.
- W3028327162 cites W2031632319 @default.
- W3028327162 cites W2034869164 @default.
- W3028327162 cites W2068597324 @default.
- W3028327162 cites W2077335475 @default.
- W3028327162 cites W2113107925 @default.
- W3028327162 cites W2133423183 @default.
- W3028327162 cites W2143206133 @default.
- W3028327162 cites W2151241903 @default.
- W3028327162 cites W2154696002 @default.
- W3028327162 cites W2164191009 @default.
- W3028327162 cites W2165604976 @default.
- W3028327162 cites W2166947492 @default.
- W3028327162 cites W2170724437 @default.
- W3028327162 cites W2293357082 @default.
- W3028327162 cites W2333117794 @default.
- W3028327162 cites W2567620261 @default.
- W3028327162 cites W2572710398 @default.
- W3028327162 cites W2581154578 @default.
- W3028327162 cites W2590423176 @default.
- W3028327162 cites W2610865917 @default.
- W3028327162 cites W2618719927 @default.
- W3028327162 cites W2727793071 @default.
- W3028327162 cites W2735609145 @default.
- W3028327162 cites W2735674855 @default.
- W3028327162 cites W2777525962 @default.
- W3028327162 cites W2808916408 @default.
- W3028327162 cites W2893505137 @default.
- W3028327162 cites W2896864601 @default.
- W3028327162 cites W2946373463 @default.
- W3028327162 cites W2963489648 @default.
- W3028327162 cites W2974136174 @default.
- W3028327162 cites W2983504269 @default.
- W3028327162 cites W2796160209 @default.
- W3028327162 doi "https://doi.org/10.14348/molcells.2020.0055" @default.
- W3028327162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7264480" @default.
- W3028327162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32392909" @default.
- W3028327162 hasPublicationYear "2020" @default.
- W3028327162 type Work @default.
- W3028327162 sameAs 3028327162 @default.
- W3028327162 citedByCount "15" @default.
- W3028327162 countsByYear W30283271622021 @default.
- W3028327162 countsByYear W30283271622022 @default.
- W3028327162 countsByYear W30283271622023 @default.
- W3028327162 crossrefType "journal-article" @default.
- W3028327162 hasAuthorship W3028327162A5012866137 @default.
- W3028327162 hasAuthorship W3028327162A5031104910 @default.
- W3028327162 hasAuthorship W3028327162A5032268144 @default.
- W3028327162 hasAuthorship W3028327162A5036363002 @default.
- W3028327162 hasConcept C126322002 @default.
- W3028327162 hasConcept C13373296 @default.
- W3028327162 hasConcept C134018914 @default.
- W3028327162 hasConcept C164027704 @default.
- W3028327162 hasConcept C2491326 @default.
- W3028327162 hasConcept C2776914184 @default.
- W3028327162 hasConcept C2777003273 @default.
- W3028327162 hasConcept C2778302649 @default.
- W3028327162 hasConcept C2778458369 @default.
- W3028327162 hasConcept C2779830541 @default.
- W3028327162 hasConcept C511355011 @default.
- W3028327162 hasConcept C71924100 @default.
- W3028327162 hasConcept C86803240 @default.
- W3028327162 hasConceptScore W3028327162C126322002 @default.
- W3028327162 hasConceptScore W3028327162C13373296 @default.
- W3028327162 hasConceptScore W3028327162C134018914 @default.
- W3028327162 hasConceptScore W3028327162C164027704 @default.
- W3028327162 hasConceptScore W3028327162C2491326 @default.
- W3028327162 hasConceptScore W3028327162C2776914184 @default.
- W3028327162 hasConceptScore W3028327162C2777003273 @default.
- W3028327162 hasConceptScore W3028327162C2778302649 @default.
- W3028327162 hasConceptScore W3028327162C2778458369 @default.
- W3028327162 hasConceptScore W3028327162C2779830541 @default.
- W3028327162 hasConceptScore W3028327162C511355011 @default.
- W3028327162 hasConceptScore W3028327162C71924100 @default.
- W3028327162 hasConceptScore W3028327162C86803240 @default.
- W3028327162 hasIssue "5" @default.
- W3028327162 hasLocation W30283271621 @default.
- W3028327162 hasOpenAccess W3028327162 @default.
- W3028327162 hasPrimaryLocation W30283271621 @default.