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- W3028366920 abstract "Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each “native” isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient “acid-spike” response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. Des simulations Monte Carlo de radiolyse de l’eau par les rayons γ de 60Co ou par des électrons rapides montrent que la formation in situ de H3O+ rend chaque région des trajectoires « natives » du rayonnement temporairement très acide. Pour une irradiation pulsée (FLASH) avec un débit de dose élevé, il est montré que cette réponse acide ultra-rapide et transitoire s’étend de manière uniforme sur la totalité du volume irradié. Puisque le pH contrôle de nombreux processus cellulaires, cette étude souligne la nécessité de considérer ces pics d’acidité dans la compréhension des mécanismes fondamentaux qui sous-tendent la radiothérapie FLASH." @default.
- W3028366920 created "2020-05-29" @default.
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- W3028366920 date "2020-07-01" @default.
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- W3028366920 title "Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment" @default.
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- W3028366920 doi "https://doi.org/10.1016/j.canrad.2019.11.004" @default.
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