Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028393875> ?p ?o ?g. }
- W3028393875 abstract "Abstract Cholinergic disorder, oxidative stress, and neuroinflammation play important roles in the pathology of Alzheimer's disease. To explore the healthy potential of the edible seaweed Hizikia fusiforme on this aspect, a functional oil (HFFO) was extracted from this alga and investigated on its constituents by gas chromatography‐mass spectrometry (GC/MS) in this study. Its anti‐Alzheimer's related bioactivities including acetylcholinesterase (AChE) inhibition, antioxidation, and anti‐neuroinflammation were evaluated, traced, and simulated by in vitro and in silico methods. GC/MS analysis indicated that HFFO mainly contained arachidonic acid (ARA), 11,14,17‐eicosatrienoic acid (ETrA), palmitic acid, phytol, etc. HFFO showed moderate AChE inhibition and antioxidant activity. Bioactivity tracing using commercial standards verified that AChE inhibition of HFFO mainly originated from ARA and ETrA, whereas antioxidant activity mainly from ARA. Lineweaver−Burk plots showed that both ARA and ETrA are noncompetitive AChE inhibitors. A molecular docking study demonstrated low CDOCKER interaction energy of −26.33 kcal/mol for ARA and −43.70 kcal/mol for ETrA when interacting with AChE and multiple interactions in the ARA (or ETrA)−AChE complex. In the anti‐neuroinflammatory evaluation, HFFO showed no toxicity toward BV‐2 cells at 20 μg/mL and effectively inhibited the production of nitroxide and reduced the level of reactive oxygen species in lipopolysaccharide‐induced BV‐2 cells. The results indicated that HFFO could be used in functional foods for its anti‐Alzheimer's disease‐related activities." @default.
- W3028393875 created "2020-05-29" @default.
- W3028393875 creator A5002188808 @default.
- W3028393875 creator A5016672459 @default.
- W3028393875 creator A5032450762 @default.
- W3028393875 creator A5038549808 @default.
- W3028393875 creator A5041553917 @default.
- W3028393875 creator A5044544424 @default.
- W3028393875 creator A5056189895 @default.
- W3028393875 creator A5056399898 @default.
- W3028393875 creator A5061405377 @default.
- W3028393875 creator A5072417757 @default.
- W3028393875 creator A5087255226 @default.
- W3028393875 date "2020-07-30" @default.
- W3028393875 modified "2023-09-27" @default.
- W3028393875 title "Chemical Composition and Anti‐Alzheimer's Disease‐Related Activities of a Functional Oil from the Edible Seaweed <i>Hizikia fusiforme</i>" @default.
- W3028393875 cites W1971048984 @default.
- W3028393875 cites W1983176088 @default.
- W3028393875 cites W1986696289 @default.
- W3028393875 cites W1991585392 @default.
- W3028393875 cites W1992332088 @default.
- W3028393875 cites W1997957289 @default.
- W3028393875 cites W1998041120 @default.
- W3028393875 cites W2003109394 @default.
- W3028393875 cites W2007621247 @default.
- W3028393875 cites W2015803832 @default.
- W3028393875 cites W2017672025 @default.
- W3028393875 cites W2020206170 @default.
- W3028393875 cites W2022284292 @default.
- W3028393875 cites W2027955282 @default.
- W3028393875 cites W2037714396 @default.
- W3028393875 cites W2046720027 @default.
- W3028393875 cites W2062341126 @default.
- W3028393875 cites W2085958374 @default.
- W3028393875 cites W2088713179 @default.
- W3028393875 cites W2089314102 @default.
- W3028393875 cites W2110719707 @default.
- W3028393875 cites W2144210822 @default.
- W3028393875 cites W2159546810 @default.
- W3028393875 cites W2192510849 @default.
- W3028393875 cites W2224271402 @default.
- W3028393875 cites W2285668279 @default.
- W3028393875 cites W2323270416 @default.
- W3028393875 cites W2606144925 @default.
- W3028393875 cites W2766388141 @default.
- W3028393875 cites W2770424213 @default.
- W3028393875 cites W2774947569 @default.
- W3028393875 cites W2789287723 @default.
- W3028393875 cites W2790709277 @default.
- W3028393875 cites W2805725390 @default.
- W3028393875 cites W2807116772 @default.
- W3028393875 cites W2809842209 @default.
- W3028393875 cites W2810927513 @default.
- W3028393875 cites W2811890554 @default.
- W3028393875 cites W2884031535 @default.
- W3028393875 cites W2884733982 @default.
- W3028393875 cites W2888930140 @default.
- W3028393875 cites W2889169432 @default.
- W3028393875 cites W2893290795 @default.
- W3028393875 cites W2903766221 @default.
- W3028393875 cites W2908201854 @default.
- W3028393875 cites W2923634234 @default.
- W3028393875 cites W4211102779 @default.
- W3028393875 doi "https://doi.org/10.1002/cbdv.202000055" @default.
- W3028393875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32419273" @default.
- W3028393875 hasPublicationYear "2020" @default.
- W3028393875 type Work @default.
- W3028393875 sameAs 3028393875 @default.
- W3028393875 citedByCount "8" @default.
- W3028393875 countsByYear W30283938752021 @default.
- W3028393875 countsByYear W30283938752022 @default.
- W3028393875 countsByYear W30283938752023 @default.
- W3028393875 crossrefType "journal-article" @default.
- W3028393875 hasAuthorship W3028393875A5002188808 @default.
- W3028393875 hasAuthorship W3028393875A5016672459 @default.
- W3028393875 hasAuthorship W3028393875A5032450762 @default.
- W3028393875 hasAuthorship W3028393875A5038549808 @default.
- W3028393875 hasAuthorship W3028393875A5041553917 @default.
- W3028393875 hasAuthorship W3028393875A5044544424 @default.
- W3028393875 hasAuthorship W3028393875A5056189895 @default.
- W3028393875 hasAuthorship W3028393875A5056399898 @default.
- W3028393875 hasAuthorship W3028393875A5061405377 @default.
- W3028393875 hasAuthorship W3028393875A5072417757 @default.
- W3028393875 hasAuthorship W3028393875A5087255226 @default.
- W3028393875 hasConcept C126322002 @default.
- W3028393875 hasConcept C181199279 @default.
- W3028393875 hasConcept C185592680 @default.
- W3028393875 hasConcept C2776151105 @default.
- W3028393875 hasConcept C2776914184 @default.
- W3028393875 hasConcept C2778004101 @default.
- W3028393875 hasConcept C2778078955 @default.
- W3028393875 hasConcept C2778816929 @default.
- W3028393875 hasConcept C2779059548 @default.
- W3028393875 hasConcept C55493867 @default.
- W3028393875 hasConcept C71924100 @default.
- W3028393875 hasConcept C87753298 @default.
- W3028393875 hasConcept C98274493 @default.
- W3028393875 hasConceptScore W3028393875C126322002 @default.
- W3028393875 hasConceptScore W3028393875C181199279 @default.
- W3028393875 hasConceptScore W3028393875C185592680 @default.