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• W3028394259 abstract "Abstract This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2 3 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content ( X p ); water activity ( A w ); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with X p and A w of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC 50 of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against Candida albicans (ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties." @default.
• W3028394259 created "2020-05-29" @default.
• W3028394259 creator A5026865254 @default.
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• W3028394259 date "2020-05-18" @default.
• W3028394259 modified "2023-10-04" @default.
• W3028394259 title "Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols" @default.
• W3028394259 cites W1219368367 @default.
• W3028394259 cites W1531664873 @default.
• W3028394259 cites W1807045809 @default.
• W3028394259 cites W1830367999 @default.
• W3028394259 cites W1965789284 @default.
• W3028394259 cites W1966952912 @default.
• W3028394259 cites W1968127015 @default.
• W3028394259 cites W1975845832 @default.
• W3028394259 cites W1979225795 @default.
• W3028394259 cites W1982329293 @default.
• W3028394259 cites W1982517101 @default.
• W3028394259 cites W1983109902 @default.
• W3028394259 cites W1985222134 @default.
• W3028394259 cites W1987370786 @default.
• W3028394259 cites W1990554339 @default.
• W3028394259 cites W1990664907 @default.
• W3028394259 cites W1991819649 @default.
• W3028394259 cites W1993458540 @default.
• W3028394259 cites W1995203863 @default.
• W3028394259 cites W1995664345 @default.
• W3028394259 cites W1997527242 @default.
• W3028394259 cites W1998154903 @default.
• W3028394259 cites W2007457116 @default.
• W3028394259 cites W2016241584 @default.
• W3028394259 cites W2019654784 @default.
• W3028394259 cites W2025086371 @default.
• W3028394259 cites W2054912434 @default.
• W3028394259 cites W2055980020 @default.
• W3028394259 cites W2067185653 @default.
• W3028394259 cites W2070808114 @default.
• W3028394259 cites W2080082430 @default.
• W3028394259 cites W2082732127 @default.
• W3028394259 cites W2083861202 @default.
• W3028394259 cites W2093511444 @default.
• W3028394259 cites W2109219296 @default.
• W3028394259 cites W2121690193 @default.
• W3028394259 cites W2124342337 @default.
• W3028394259 cites W2127469605 @default.
• W3028394259 cites W2128926638 @default.
• W3028394259 cites W2129133439 @default.
• W3028394259 cites W2132044699 @default.
• W3028394259 cites W2133469765 @default.
• W3028394259 cites W2138575795 @default.
• W3028394259 cites W2152252699 @default.
• W3028394259 cites W2162180554 @default.
• W3028394259 cites W2167424604 @default.
• W3028394259 cites W2170832294 @default.
• W3028394259 cites W2233867768 @default.
• W3028394259 cites W2260388079 @default.
• W3028394259 cites W2272032077 @default.
• W3028394259 cites W2274901278 @default.
• W3028394259 cites W2292003813 @default.
• W3028394259 cites W2293851989 @default.
• W3028394259 cites W2318447749 @default.
• W3028394259 cites W2320333633 @default.
• W3028394259 cites W2336605531 @default.
• W3028394259 cites W2464356132 @default.
• W3028394259 cites W2496930211 @default.
• W3028394259 cites W2505884284 @default.
• W3028394259 cites W2530082386 @default.
• W3028394259 cites W2557265782 @default.
• W3028394259 cites W2561242958 @default.
• W3028394259 cites W2561287072 @default.
• W3028394259 cites W2597556592 @default.
• W3028394259 cites W2617466023 @default.
• W3028394259 cites W2624151100 @default.
• W3028394259 cites W2735211779 @default.
• W3028394259 cites W2785665631 @default.
• W3028394259 cites W2802131101 @default.
• W3028394259 cites W2891260222 @default.
• W3028394259 cites W2898908573 @default.
• W3028394259 cites W2910083069 @default.
• W3028394259 cites W2911275335 @default.
• W3028394259 cites W2914676175 @default.
• W3028394259 cites W3138270874 @default.
• W3028394259 cites W324980121 @default.
• W3028394259 cites W4243693844 @default.
• W3028394259 cites W4248954065 @default.
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• W3028394259 doi "https://doi.org/10.1208/s12249-020-01668-2" @default.
• W3028394259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7235052" @default.
• W3028394259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32424702" @default.
• W3028394259 hasPublicationYear "2020" @default.
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