FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028394313> ?p ?o ?g. }

• W3028394313 abstract "Colitis is associated with the development of colorectal cancer (CRC) by largely undefined mechanisms that are critical for understanding the link between inflammation and cancer. Intestinal stem cells (ISCs) marked by leucine-rich repeat–containing G protein–coupled receptor 5 (LGR5) expression are of importance in both the inflammatory response to colitis and progression to colitis-associated colon cancer (CACC). Here, we report in human mucin 1–transgenic (MUC1-transgenic) mouse models of CACC, targeting the MUC1-C oncogenic protein suppresses the (a) Lgr5+ ISC population, (b) induction of Myc and core pluripotency stem cell factors, and (c) severity and progression of colitis to dysplasia and cancer. By extension to human colon cancer cells, we demonstrate that MUC1-C drives MYC, forms a complex with MYC on the LGR5 promoter, and activates LGR5 expression. We also show in CRC cells that MUC1-C induces cancer stem cell (CSC) markers (BMI1, ALDH1, FOXA1, LIN28B) and the OCT4, SOX2, and NANOG pluripotency factors. Consistent with conferring the CSC state, targeting MUC1-C suppresses the capacity of CRC cells to promote wound healing, invasion, self-renewal, and tumorigenicity. In analysis of human tissues, MUC1 expression associates with activation of inflammatory pathways, development of colitis, and aggressiveness of CRCs. These results collectively indicate that MUC1-C is of importance for integrating stemness and pluripotency in colitis and CRC. Of clinical relevance, the findings further indicate that MUC1-C represents a potentially previously unrecognized target that is druggable for treating progression of colitis and CRC." @default.
• W3028394313 created "2020-05-29" @default.
• W3028394313 creator A5000432967 @default.
• W3028394313 creator A5008039836 @default.
• W3028394313 creator A5010364407 @default.
• W3028394313 creator A5010396290 @default.
• W3028394313 creator A5014295844 @default.
• W3028394313 creator A5017943660 @default.
• W3028394313 creator A5018244700 @default.
• W3028394313 creator A5028515700 @default.
• W3028394313 creator A5036702416 @default.
• W3028394313 creator A5037062908 @default.
• W3028394313 creator A5041333444 @default.
• W3028394313 creator A5049901416 @default.
• W3028394313 creator A5054418515 @default.
• W3028394313 creator A5056585446 @default.
• W3028394313 creator A5066431768 @default.
• W3028394313 creator A5067054634 @default.
• W3028394313 creator A5075105508 @default.
• W3028394313 date "2020-06-18" @default.
• W3028394313 modified "2023-10-17" @default.
• W3028394313 title "MUC1-C drives stemness in progression of colitis to colorectal cancer" @default.
• W3028394313 cites W1853854707 @default.
• W3028394313 cites W1956018566 @default.
• W3028394313 cites W1987384630 @default.
• W3028394313 cites W1996344455 @default.
• W3028394313 cites W1999294081 @default.
• W3028394313 cites W2003299661 @default.
• W3028394313 cites W2008176496 @default.
• W3028394313 cites W2010571201 @default.
• W3028394313 cites W2017218715 @default.
• W3028394313 cites W2018075167 @default.
• W3028394313 cites W2021360119 @default.
• W3028394313 cites W2027266715 @default.
• W3028394313 cites W2029556699 @default.
• W3028394313 cites W2030702612 @default.
• W3028394313 cites W2034102636 @default.
• W3028394313 cites W2034451570 @default.
• W3028394313 cites W2035644586 @default.
• W3028394313 cites W2041769554 @default.
• W3028394313 cites W2052394132 @default.
• W3028394313 cites W2061965920 @default.
• W3028394313 cites W2073759231 @default.
• W3028394313 cites W2089643849 @default.
• W3028394313 cites W2090562908 @default.
• W3028394313 cites W2107575419 @default.
• W3028394313 cites W2108778111 @default.
• W3028394313 cites W2125987139 @default.
• W3028394313 cites W2135109255 @default.
• W3028394313 cites W2146426819 @default.
• W3028394313 cites W2164740289 @default.
• W3028394313 cites W2270139959 @default.
• W3028394313 cites W2273261885 @default.
• W3028394313 cites W2273958019 @default.
• W3028394313 cites W2321327051 @default.
• W3028394313 cites W2323342584 @default.
• W3028394313 cites W2339445632 @default.
• W3028394313 cites W2406732664 @default.
• W3028394313 cites W2504834794 @default.
• W3028394313 cites W2508743435 @default.
• W3028394313 cites W2520711232 @default.
• W3028394313 cites W2523322270 @default.
• W3028394313 cites W2557697459 @default.
• W3028394313 cites W2598830924 @default.
• W3028394313 cites W2599835027 @default.
• W3028394313 cites W2739961143 @default.
• W3028394313 cites W2777824761 @default.
• W3028394313 cites W2785091318 @default.
• W3028394313 cites W2790601065 @default.
• W3028394313 cites W2810636731 @default.
• W3028394313 cites W2892185704 @default.
• W3028394313 cites W2912384789 @default.
• W3028394313 cites W2914571649 @default.
• W3028394313 cites W2943966410 @default.
• W3028394313 cites W2950359183 @default.
• W3028394313 cites W2956402954 @default.
• W3028394313 cites W2959417818 @default.
• W3028394313 cites W2959497269 @default.
• W3028394313 cites W2969893943 @default.
• W3028394313 cites W2970045605 @default.
• W3028394313 cites W2973164205 @default.
• W3028394313 cites W2985983100 @default.
• W3028394313 cites W2991437081 @default.
• W3028394313 cites W2993314083 @default.
• W3028394313 cites W2999646405 @default.
• W3028394313 doi "https://doi.org/10.1172/jci.insight.137112" @default.
• W3028394313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7406273" @default.
• W3028394313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32427590" @default.
• W3028394313 hasPublicationYear "2020" @default.
• W3028394313 type Work @default.
• W3028394313 sameAs 3028394313 @default.
• W3028394313 citedByCount "32" @default.
• W3028394313 countsByYear W30283943132020 @default.
• W3028394313 countsByYear W30283943132021 @default.
• W3028394313 countsByYear W30283943132022 @default.
• W3028394313 countsByYear W30283943132023 @default.
• W3028394313 crossrefType "journal-article" @default.
• W3028394313 hasAuthorship W3028394313A5000432967 @default.
• W3028394313 hasAuthorship W3028394313A5008039836 @default.
• W3028394313 hasAuthorship W3028394313A5010364407 @default.

• next