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- W3028429224 endingPage "105372" @default.
- W3028429224 startingPage "105372" @default.
- W3028429224 abstract "Current oral squamous cell carcinoma chemotherapies demonstrate off-target toxicity, which could be reduced by local delivery. Curcumin acts via many cellular targets to give anti-cancer properties; however the bioavailability is hindered by its physicochemical characteristics. The incorporation of curcumin into emulgel systems could be a promising approach for its solubilization and delivery. The aim of this work was to develop emulgel systems containing curcumin for the treatment of oral cancer. The emulgels containing curcumin were prepared with poloxamer 407, acrylic acid derivatives, oil phase (sesame oil or isopropyl myristate). The more stable system was evaluated for mechanical and rheological properties, as well as, the in vitro drug release profile, permeation and cytotoxic potential to oral mucosa models. The flow-throw system evidenced that the formulations could keep 5 min over porcine oral mucosa. Emulgel showed pseudoplastic behavior and a gelation temperature of 33 °C, which ensure their higher consistency. In addition, 70% of the incorporated curcumin was released within 24 h in an in vitro drug release study and could permeate porcine oral mucosa. Monolayers cultures and tissue-engineered models showed the selectivity of the drug and systems for tumor cells. The physicochemical properties, subsequent release and permeation of curcumin to selectivity kill cancer cells could be improved by the incorporation into emulgel systems." @default.
- W3028429224 created "2020-05-29" @default.
- W3028429224 creator A5033111944 @default.
- W3028429224 creator A5052115473 @default.
- W3028429224 creator A5065764448 @default.
- W3028429224 creator A5066689668 @default.
- W3028429224 creator A5079638009 @default.
- W3028429224 creator A5090449866 @default.
- W3028429224 date "2020-08-01" @default.
- W3028429224 modified "2023-10-17" @default.
- W3028429224 title "Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: From pre-formulation to cytotoxicity in tissue-engineering oral mucosa" @default.
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