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- W3028468570 endingPage "1027" @default.
- W3028468570 startingPage "1015" @default.
- W3028468570 abstract "Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase (TERT) is repressed and telomerase activity is inhibited. This leads to the progressive shortening of telomeres and inhibition of cell growth in a process called replicative senescence. Most types of primary cancer exhibit telomerase activation, which allows uncontrolled cell proliferation. Previous research indicates that TERT activation also affects cancer development through activities other than the canonical function of mediating telomere elongation. Recent studies have improved the understanding of the structure and function of telomeres and telomerase as well as key mechanisms underlying the activation of TERT and its role in oncogenesis. These advances led to a search for drugs that inhibit telomerase as a target for cancer therapy. The present review article summarizes the organization and function of telomeres, their role in carcinogenesis, and advances in telomerase-targeted therapy." @default.
- W3028468570 created "2020-05-29" @default.
- W3028468570 creator A5022580561 @default.
- W3028468570 creator A5030049075 @default.
- W3028468570 creator A5036633111 @default.
- W3028468570 creator A5047524962 @default.
- W3028468570 date "2020-05-21" @default.
- W3028468570 modified "2023-10-17" @default.
- W3028468570 title "Telomeres and telomerase in oncogenesis (Review)" @default.
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