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• W3028496843 endingPage "102868" @default.
• W3028496843 startingPage "102868" @default.
• W3028496843 abstract "Regions of genomic DNA can become single-stranded in the course of normal replication and transcription as well as during DNA repair. Abnormal repair and replication intermediates can contain large stretches of persistent single-stranded DNA, which is extremely vulnerable to DNA damaging agents and hypermutation. Since such single-stranded DNA spans only a fraction of the genome at a given instance, hypermutation in these regions leads to tightly-spaced mutation clusters. This phenomenon of hypermutation in single-stranded DNA has been documented in several experimental models as well as in cancer genomes. Recently, hypermutated single-stranded RNA viral genomes also have been documented. Moreover, indications of hypermutation in single-stranded DNA may also be found in the human germline. This review will summarize key current knowledge and the recent developments in understanding the diverse mechanisms and sources of ssDNA hypermutation." @default.
• W3028496843 created "2020-05-29" @default.
• W3028496843 creator A5051424102 @default.
• W3028496843 creator A5063124326 @default.
• W3028496843 date "2020-07-01" @default.
• W3028496843 modified "2023-10-11" @default.
• W3028496843 title "Hypermutation in single-stranded DNA" @default.
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