Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028522379> ?p ?o ?g. }
- W3028522379 endingPage "e1007793" @default.
- W3028522379 startingPage "e1007793" @default.
- W3028522379 abstract "Non-coding RNAs are fundamental to the competing endogenous RNA (CeRNA) hypothesis in oncology. Previous work focused on static CeRNA networks. We construct and analyze CeRNA networks for four sequential stages of lung adenocarcinoma (LUAD) based on multi-omics data of long non-coding RNAs (lncRNAs), microRNAs and mRNAs. We find that the networks possess a two-level bipartite structure: common competing endogenous network (CCEN) composed of an invariant set of microRNAs over all the stages and stage-dependent, unique competing endogenous networks (UCENs). A systematic enrichment analysis of the pathways of the mRNAs in CCEN reveals that they are strongly associated with cancer development. We also find that the microRNA-linked mRNAs from UCENs have a higher enrichment efficiency. A key finding is six microRNAs from CCEN that impact patient survival at all stages, and four microRNAs that affect the survival from a specific stage. The ten microRNAs can then serve as potential biomarkers and prognostic tools for LUAD." @default.
- W3028522379 created "2020-05-29" @default.
- W3028522379 creator A5041910942 @default.
- W3028522379 creator A5050109554 @default.
- W3028522379 creator A5053306246 @default.
- W3028522379 creator A5055865902 @default.
- W3028522379 creator A5067690714 @default.
- W3028522379 creator A5073768295 @default.
- W3028522379 creator A5089707942 @default.
- W3028522379 date "2020-05-19" @default.
- W3028522379 modified "2023-10-18" @default.
- W3028522379 title "Dynamical network analysis reveals key microRNAs in progressive stages of lung cancer" @default.
- W3028522379 cites W1525117983 @default.
- W3028522379 cites W1820723315 @default.
- W3028522379 cites W1835981532 @default.
- W3028522379 cites W1967424629 @default.
- W3028522379 cites W1972892962 @default.
- W3028522379 cites W1972989638 @default.
- W3028522379 cites W1985400174 @default.
- W3028522379 cites W1988163167 @default.
- W3028522379 cites W1991153319 @default.
- W3028522379 cites W1995082021 @default.
- W3028522379 cites W2001155312 @default.
- W3028522379 cites W2016106370 @default.
- W3028522379 cites W2046387002 @default.
- W3028522379 cites W2053907825 @default.
- W3028522379 cites W2054841768 @default.
- W3028522379 cites W2064039900 @default.
- W3028522379 cites W2071480068 @default.
- W3028522379 cites W2071776031 @default.
- W3028522379 cites W2078564924 @default.
- W3028522379 cites W2081098333 @default.
- W3028522379 cites W2084706776 @default.
- W3028522379 cites W2087377443 @default.
- W3028522379 cites W2088720324 @default.
- W3028522379 cites W2097302215 @default.
- W3028522379 cites W2102304447 @default.
- W3028522379 cites W2102326716 @default.
- W3028522379 cites W2105493915 @default.
- W3028522379 cites W2111661781 @default.
- W3028522379 cites W2115356925 @default.
- W3028522379 cites W2115530814 @default.
- W3028522379 cites W2128768066 @default.
- W3028522379 cites W2130687298 @default.
- W3028522379 cites W2134118500 @default.
- W3028522379 cites W2143662314 @default.
- W3028522379 cites W2145361279 @default.
- W3028522379 cites W2146512944 @default.
- W3028522379 cites W2147668950 @default.
- W3028522379 cites W2153265806 @default.
- W3028522379 cites W2154551754 @default.
- W3028522379 cites W2158135353 @default.
- W3028522379 cites W2159864284 @default.
- W3028522379 cites W2162674813 @default.
- W3028522379 cites W2165515236 @default.
- W3028522379 cites W2168793216 @default.
- W3028522379 cites W2176018013 @default.
- W3028522379 cites W2180481128 @default.
- W3028522379 cites W2182375217 @default.
- W3028522379 cites W2191329868 @default.
- W3028522379 cites W2196543065 @default.
- W3028522379 cites W2246653280 @default.
- W3028522379 cites W2268565105 @default.
- W3028522379 cites W2275877493 @default.
- W3028522379 cites W2308318152 @default.
- W3028522379 cites W2405799505 @default.
- W3028522379 cites W2444348215 @default.
- W3028522379 cites W2530294125 @default.
- W3028522379 cites W2587636834 @default.
- W3028522379 cites W2602656443 @default.
- W3028522379 cites W2621312652 @default.
- W3028522379 cites W2741363425 @default.
- W3028522379 cites W2758499822 @default.
- W3028522379 cites W2766126935 @default.
- W3028522379 cites W2768096340 @default.
- W3028522379 cites W2770715352 @default.
- W3028522379 cites W2776508475 @default.
- W3028522379 cites W2781525129 @default.
- W3028522379 cites W2784207258 @default.
- W3028522379 cites W2793353518 @default.
- W3028522379 cites W2883915660 @default.
- W3028522379 cites W2883963675 @default.
- W3028522379 cites W2885764767 @default.
- W3028522379 cites W2887262889 @default.
- W3028522379 cites W2894860758 @default.
- W3028522379 cites W2905054950 @default.
- W3028522379 cites W2905101550 @default.
- W3028522379 cites W2917837889 @default.
- W3028522379 cites W2972287571 @default.
- W3028522379 cites W2973056123 @default.
- W3028522379 cites W3099018540 @default.
- W3028522379 cites W4234236664 @default.
- W3028522379 cites W4293241248 @default.
- W3028522379 cites W612343255 @default.
- W3028522379 doi "https://doi.org/10.1371/journal.pcbi.1007793" @default.
- W3028522379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7295246" @default.
- W3028522379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32428028" @default.
- W3028522379 hasPublicationYear "2020" @default.