Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028579353> ?p ?o ?g. }
- W3028579353 endingPage "1251" @default.
- W3028579353 startingPage "1251" @default.
- W3028579353 abstract "Pancreatic ductal adenocarcinoma (PDAC) correlates with high mortality and is about to become one of the major reasons for cancer-related mortality in the next decades. One reason for that high mortality is the limited availability of effective chemotherapy as well as the intrinsic or acquired resistance against it. Here, we report the impact of nab-paclitaxel on the cellular metabolome of PDAC cell lines. After establishment of nab-paclitaxel resistant cell lines, comparison of parental and resistant PDAC cell lines by metabolomics and biochemical assessments revealed altered metabolism, enhanced viability and reduced apoptosis. The results unveiled that acute nab-paclitaxel treatment affected primary metabolism to a minor extent. However, acquisition of resistance led to altered metabolites in both cell lines tested. Specifically, aspartic acid and carbamoyl-aspartic acid were differentially abundant, which might indicate an increased de novo pyrimidine synthesis. This pathway has already shown a similar behavior in other cancerous entities and thus might serve in the future as vulnerable target fighting resistance acquisition occurring in common malignancies." @default.
- W3028579353 created "2020-05-29" @default.
- W3028579353 creator A5034128863 @default.
- W3028579353 creator A5043212478 @default.
- W3028579353 creator A5047423734 @default.
- W3028579353 creator A5080709924 @default.
- W3028579353 creator A5086810137 @default.
- W3028579353 creator A5088445750 @default.
- W3028579353 date "2020-05-19" @default.
- W3028579353 modified "2023-09-26" @default.
- W3028579353 title "Metabolic Adaptation during nab-Paclitaxel Resistance in Pancreatic Cancer Cell Lines" @default.
- W3028579353 cites W1480437404 @default.
- W3028579353 cites W1691784839 @default.
- W3028579353 cites W1931508686 @default.
- W3028579353 cites W1968812902 @default.
- W3028579353 cites W1979811394 @default.
- W3028579353 cites W1984328540 @default.
- W3028579353 cites W1986249544 @default.
- W3028579353 cites W2010317454 @default.
- W3028579353 cites W2010916968 @default.
- W3028579353 cites W2021364553 @default.
- W3028579353 cites W2026108602 @default.
- W3028579353 cites W2028117656 @default.
- W3028579353 cites W2036028332 @default.
- W3028579353 cites W2036919765 @default.
- W3028579353 cites W2039225116 @default.
- W3028579353 cites W2049894527 @default.
- W3028579353 cites W2050253364 @default.
- W3028579353 cites W2052460031 @default.
- W3028579353 cites W2055397209 @default.
- W3028579353 cites W2060490244 @default.
- W3028579353 cites W2061797905 @default.
- W3028579353 cites W2077998713 @default.
- W3028579353 cites W2081027426 @default.
- W3028579353 cites W2096289704 @default.
- W3028579353 cites W2102509488 @default.
- W3028579353 cites W2110050868 @default.
- W3028579353 cites W2122008991 @default.
- W3028579353 cites W2122922085 @default.
- W3028579353 cites W2128198307 @default.
- W3028579353 cites W2129051737 @default.
- W3028579353 cites W2132235170 @default.
- W3028579353 cites W2151253787 @default.
- W3028579353 cites W2151767652 @default.
- W3028579353 cites W2156307784 @default.
- W3028579353 cites W2157590016 @default.
- W3028579353 cites W2165480504 @default.
- W3028579353 cites W2184169423 @default.
- W3028579353 cites W2188531629 @default.
- W3028579353 cites W2192943385 @default.
- W3028579353 cites W2223535266 @default.
- W3028579353 cites W2234115940 @default.
- W3028579353 cites W2337098752 @default.
- W3028579353 cites W2343948994 @default.
- W3028579353 cites W2409321676 @default.
- W3028579353 cites W2531263374 @default.
- W3028579353 cites W2590002384 @default.
- W3028579353 cites W2592487518 @default.
- W3028579353 cites W2746094882 @default.
- W3028579353 cites W2789580808 @default.
- W3028579353 cites W2790373925 @default.
- W3028579353 cites W2800389517 @default.
- W3028579353 cites W2803664483 @default.
- W3028579353 cites W2909072029 @default.
- W3028579353 cites W2942548029 @default.
- W3028579353 cites W2950705205 @default.
- W3028579353 cites W2977045527 @default.
- W3028579353 cites W3009043826 @default.
- W3028579353 cites W4210976084 @default.
- W3028579353 doi "https://doi.org/10.3390/cells9051251" @default.
- W3028579353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7290296" @default.
- W3028579353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32438599" @default.
- W3028579353 hasPublicationYear "2020" @default.
- W3028579353 type Work @default.
- W3028579353 sameAs 3028579353 @default.
- W3028579353 citedByCount "9" @default.
- W3028579353 countsByYear W30285793532021 @default.
- W3028579353 countsByYear W30285793532022 @default.
- W3028579353 countsByYear W30285793532023 @default.
- W3028579353 crossrefType "journal-article" @default.
- W3028579353 hasAuthorship W3028579353A5034128863 @default.
- W3028579353 hasAuthorship W3028579353A5043212478 @default.
- W3028579353 hasAuthorship W3028579353A5047423734 @default.
- W3028579353 hasAuthorship W3028579353A5080709924 @default.
- W3028579353 hasAuthorship W3028579353A5086810137 @default.
- W3028579353 hasAuthorship W3028579353A5088445750 @default.
- W3028579353 hasBestOaLocation W30285793531 @default.
- W3028579353 hasConcept C121608353 @default.
- W3028579353 hasConcept C135870905 @default.
- W3028579353 hasConcept C190283241 @default.
- W3028579353 hasConcept C21565614 @default.
- W3028579353 hasConcept C2777292972 @default.
- W3028579353 hasConcept C2780210213 @default.
- W3028579353 hasConcept C502942594 @default.
- W3028579353 hasConcept C54355233 @default.
- W3028579353 hasConcept C55493867 @default.
- W3028579353 hasConcept C60644358 @default.
- W3028579353 hasConcept C81885089 @default.