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- W3028602352 abstract "ObjectiveTo investigate mutations of S protein gene in positive HBsAg and anti-HBs patients with chronic hepatitis B virus (HBV) infection.MethodsFifteen HBsAg(+ ) and anti-HBs(+ ) patients and 22 HBsAg(+ ) and anti-HBs(-) patients (control group) admitted in Renmin Hospital of Wuhan University during January and December 2011 were enrolled in the study. The S protein gene was amplified and sequenced, and the amino acid sequences were translated from the obtained DNA sequences and compared with the reference sequences.ResultsCompared with the control group, HBsAg(+ ) and anti-HBs(+ ) patients showed a higher variability in amino acid within major hydrophilic region (2.95 vs. 0.78, χ2=18.059, P<0.01) and theadeterminant (4.44 vs. 1.52, χ2=6.985, P<0.01). The mutations inadeterminant at positions P127T, G130E, G130N, M133S, F134I, T140I and G145R were detected only in HBsAg(+ ) and anti-HBs(+ ) patients.ConclusionCo-existence of HBsAg and anti-HBs in patients with chronic HBV infection might be associated with the increased amino acid mutations in and around theadeterminant of protein S.Key words: Hepatitis B virus; Hepatitis B surface antigens; Hepatitis B antibodies; DNA mutational analysis" @default.
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- W3028602352 date "2015-12-28" @default.
- W3028602352 modified "2023-09-23" @default.
- W3028602352 title "Mutations of S protein gene in positive HBsAg and anti-HBs patients with chronic hepatitis B virus infection" @default.
- W3028602352 doi "https://doi.org/10.3760/cma.j.issn.1674-2397.2015.06.005" @default.
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