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• W3028605950 endingPage "103876" @default.
• W3028605950 startingPage "103876" @default.
• W3028605950 abstract "High-frequency material behavior of cartilage at macroscopic lengths is not widely understood, despite a wide range of frequencies and contact lengths experienced in vivo. For example, cartilage at different stages of matrix integrity can experience high-frequency loading during traumatic impact, making high-frequency behavior relevant in the context of structural failure. Therefore, this study examined macroscopic dissipative and mechanical responses of intact and glycosaminoglycan (GAG)-depleted cartilage under previously unexplored high-frequency loading. These dynamic responses were complemented with the evaluation of quasi-static responses. A custom dynamic mechanical analyzer was used to obtain dynamic behavior, and stress relaxation testing was performed to obtain quasi-static behavior. Under high-frequency loading, cartilage energy dissipation increased with GAG depletion and decreased with strain; dynamic modulus exhibited opposite trends. Similarly, under quasi-static loading, equilibrium modulus and relaxation time of cartilage decreased with GAG depletion. The increased energy dissipation after GAG depletion under high-frequency loading was likely due to increased viscoelastic dissipation. These findings broaden our understanding of fundamental properties of cartilage as a function of solid matrix integrity in an unprecedented loading regime. They also provide a foundation for analyzing energy dissipation associated with cartilage failure induced by traumatic impact." @default.
• W3028605950 created "2020-06-05" @default.
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• W3028605950 date "2020-10-01" @default.
• W3028605950 modified "2023-09-29" @default.
• W3028605950 title "Glycosaminoglycan depletion increases energy dissipation in articular cartilage under high-frequency loading" @default.
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• W3028605950 doi "https://doi.org/10.1016/j.jmbbm.2020.103876" @default.
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