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- W3028610367 abstract "Objective To prove the expression of PPARγ in human pituitary adenomas,and administrate that the expression among different tumors has significant difference.Method 83 cases of pituitary adenoma tissues and 6 normal pituitary tissues were divided into different groups by immunohischemieal according to the source of tissues and cells.The mRNA of PPARγ in 83 pituitary adenomas tissues and 6 normal pituitary tissues were determined by RT-PCR and quantitative real-time PCR,the protein of PPARγ were detected by western-blot.Result we have 89 samples,17 samples tested as GH secreting-adenomas,15 samples tested as PRL secreting-adenomas,18 samples tested as ACTH secreting-adenomas,17 samples tested as miscellaneous pituitary adenomas (MCPAs),16 samples tested as nonfunctional pituitary adenomas (NFAs) and 6 samples tested as normal;the PPARγ mRNA expressions were higher in all kinds of pituitary adenomas than in the normal pituitary tissue.GH secreting-adenomas was the highest,and the differentia was significant in statistics;the protein expression level of PPARγ in GH secreting,Prolactin secreting,ATCH secreting and MCPAs were higher than in the normal pituitary tissue (P＜0.05),and the expression in GH secreting-adenomas was the highest which has markedly differentia.The expression level of NFAs has no different compared with normal pituitary (P＞0.05).Conclusion We supposed that PPARγ is an important molecular target in pituitary adenoma cells,especially for GH secreting-adenomas.Key words: PPARγ; Pituitary adenoma; GH secreting-adenoma; Nonfunctioning pituitary adenoma" @default.
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- W3028610367 date "2009-10-28" @default.
- W3028610367 modified "2023-09-23" @default.
- W3028610367 title "Correlation of peroxisome proliferation-activated receptor in pituitary adenoma" @default.
- W3028610367 doi "https://doi.org/10.3760/cma.j.issn.1001-2346.2009.010.011" @default.
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