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- W3028615475 abstract "ObjectiveTo evaluate the safety of Cardiac Shock Wave Therapy (CSWT) on the normal rat heart.MethodsTwelve rats were randomly divided into control group (NC, n=6) and Shock Wave (SW) treated group (NC+ SW, n=6). All animals were sacrificed 24 hours after SW treatment to collect specimens.Hematoxylin and eosin (HE) staining was used for histopathology examination, and cell apoptosis rate was determined by TUNEL staining.Apoptosis related proteins expression was analyzed by Western blotting.ResultsHE staining revealed that there was no obviously degeneration, necrosis, fibrous hyperplasia or inflammatory cell infiltration in the NC and SW treated hearts.TUNEL staining showed apoptosis rate of cardiomyocyte was not increased in SW treated group compared with NC group (5.38%±0.81% vs.5.83%±0.44%, P=0.64). Western blot analysis revealed that expressions of Bcl-2 (1.02±0.03 vs.0.92±0.04, P=0.09), Bax (0.55±0.01 vs.0.51±0.02, P=0.05), cleaved Caspase-3 (0.220±0.005 vs.0.230±0.003, P=0.39) were no significant differences between the two groups.Also, the level of mitochondrial cytochrome C of SW treated group was similar to the NC group (1.49±0.08 vs.1.36±0.07, P=0.25). There was no significant differences of the phosphorylation of JNK, p38MAPK and Akt between the two groups.Hemodynamic monitoring showed that systolic blood pressure [(120.6±2.0) mmHg vs.(121.4±1.4) mmHg, P=0.75], diastolic blood pressure [(91.2±1.0) mmHg vs.(89.4±1.5) mmHg, P=0.35] and heart rate [(343.2±5.8) beats/min vs.(334.3±6.6) beats/min, P=0.34] were not significantly different.ConclusionsCSWT is a safe treatment for adult rat.Key words: Cardiac shock wave therapy; Myocytes, cardiac; Apoptosis; Safety" @default.
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- W3028615475 date "2016-04-25" @default.
- W3028615475 modified "2023-09-23" @default.
- W3028615475 title "Safety studies on cardiac shock wave therapy on heart" @default.
- W3028615475 doi "https://doi.org/10.3969/j.issn.1007-5410.2016.02.011" @default.
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