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- W3028631397 abstract "Objective To investigate the clinical significance of detecting soluble platelet glycocal-icin (sGC) and thrombopoietin (TPO) in the differential diagnosis of idiopathic thrombocytopenic purpura (ITP) and aplastic anemia (AA). Methods Plasma sGC and serum TPO in 83 patients with ITP, 47 pa-tients with AA and 50 normal individuals were detected by iminunoradiometric assay (IRMA) and enzyme-linked immunosorbent assay (ELISA), respectively. Statistical analysis was performed using Q test and P value of 0.05). But serum TPO level in AA group was significantly higher than that in ITP and normal groups: (857.43±228.43) ng/L vs (90.32±39.43) ng/L and (70.29±25.16) ng/L, and they were considered statistically significant (Q=24.45 and 18.25, both P < 0.01). Conclusion Detecting plasma sGC and serum TPO might be helpful for differentiating ITP and AA and for understanding the pathophysiol-ogy of thrombocytopenia.Key words: Purpura, thrombocytopenic; Anemia, aplastic; Platelet membrane glycoprotenis; Thrombopoietiu; Immuoradiometric assay; Enzyme-linked immunosorbent assay" @default.
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- W3028631397 date "2010-04-25" @default.
- W3028631397 modified "2023-09-26" @default.
- W3028631397 title "Clinical significance of detecting soluble glycocalicin and thrombopoietin in the differential diagnosis of idiopathic thrombocytopenic purpura and aplastic anemia" @default.
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