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- W3028681197 abstract "ObjectiveTo analyze the effects of gross tumor volume (GTV-T) and positive lymph node volume (GTV-LN) on the prognosis of radical concurrent chemoradiotherapy for esophageal squamous cell carcinoma (ESCC).MethodsA total of 79 patients with stage N1 ESCC undergoing radical radiotherapy in our hospital from 2012 to 2015 were enrolled as subjects. GTV-T and GTV-LN were calculated by the Pinnacle3 9.0 treatment planning system. The receiver operating characteristic (ROC) curves were used to evaluate the value of the GTV-LN/GTV-T ratio in the prediction of local recurrence (LR) and distant metastasis (DM) of ESCC.ResultsThe median follow-up time was 17.2 months in all patients. The ROC curves were made using the GTV-LN/GTV-T ratio. The optimal cut-off values of GTV-LN/GTV-T ratio for predicting the risk of LR and DM were 0.34 and 0.59, respectively. The statistical analysis revealed that the LR rates were 50% and 8% in patients with GTV-LN/GTV-T ratios of<0.34 and ≥0.34, respectively (P<0.01), while the DM rates were 11% and 43% in patients with GTV-LN/GTV-T ratios of<0.59 and ≥0.59, respectively (P=0.003).ConclusionsThe GTV-LN/GTV-T ratio may be a predictor of LR and DM in patients with ESCC. Further studies on the GTV-LN/GTV-T ratio may help to make personalized chemoradiotherapy strategies for patients with ESCC.Key words: Esophageal neoplasms/radiochemotherapy; Gross tumor volume; Prognosis" @default.
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- W3028681197 date "2017-12-15" @default.
- W3028681197 modified "2023-09-28" @default.
- W3028681197 title "Effects of gross tumor volume and positive lymph node volume on prognosis of intensity-modulated radiotherapy for esophageal squamous cell carcinoma" @default.
- W3028681197 doi "https://doi.org/10.3760/cma.j.issn.1004-4221.2017.12.007" @default.
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