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- W3028687130 abstract "目的 调查中国南方地区健康人群和动脉瘤性蛛网膜下腔出血(aSAH)患者的载脂蛋白E(APOE)基因型和频率分布特点,探讨APOE基因型与aSAH发病的关系.方法检测133例aSAH患者和127名志愿者外周血APOE基因型,分析病例组和对照组各基因型和等位基因的频率,计算APOE基因型与aSAH发病的相关系数.结果病例组e4等位基因频率与对照组相比有显著性差异(P＜0.05);e2和e3等位基因频率与对照组比较无显著性差异(P＞0.05);e4基因型携带者发生aSAH的危险度较非e4携带者高1.7倍(OR=1.72);e2和e3基因型携带者发生aSAH的危险性与对照组相比无升高(比值比分别为0.71和0.98).结论 APOEe4基因是中国南方部分地区人群aSAH发病的危险因子。" @default.
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- W3028687130 date "2006-05-15" @default.
- W3028687130 modified "2023-09-25" @default.
- W3028687130 title "The influence of apolipoprotein E genotype on the onset of aneurysmal subarachnoid hemorrhagecorrelation" @default.
- W3028687130 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2006.05.009" @default.
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