Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028688614> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3028688614 endingPage "2377" @default.
- W3028688614 startingPage "2375" @default.
- W3028688614 abstract "ObjectiveTo assess whether combined apoptosis signal regulating kinase 1 inhibitor (ASK-1I) with angiotensin-converting-enzyme inhibitor (ACEI) could achieve enhanced benefits compared to monotherapy on 5/6 nephrectomy rats.MethodsAdult male Sprague Dawley rats underwent 5/6 nephrectomy (5/6 Nx) at week 0 and renal biopsy at week 8. Rats were randomized to four groups with equal glomerulosclerosis: control group, ASK-1 inhibitor group, ACEI group and combination group. After treatment for 4 weeks, animals were sacrificed at week 12. Systolic blood pressure (SBP), albumin to creatinine ratio (ACR), serum creatinine and creatinine clearance rate (Ccr) were measured at intervals. At week 8 and 12, the degree of glomerulosclerosis was evaluated.ResultsAll rats developed hypertension, proteinuria and glomerulosclerosis from week 0 to 8. At 12th week, blood pressure (BP) in ACEI group was significantly lower than in control group (P<0.05). ACR growth rate in ACEI group and combination group was significantly lower than in control group [(57.8±24.4)%, (50.2±27.5)%, (244.9±69.4)% respectively, P<0.05]. Creatinine growth rate in ASK-1 inhibitor group and combination group was lower than in control group [(19.1±17.5)%, (22.3±17.7)%, (89.8±24.7)% respectively, P<0.05]. Simultaneously, the glomerulosclerosis could be effectively reversed in combination group (P<0.05).ConclusionCombined use of ASK-1I with ACEI can reduce BP, proteinuria and glomerulosclerosis significantly, and can improve renal function.Key words: Apoptosis signal regulating kinase 1 inhibitor; Angiotensin-converting-enzyme inhibitor; Albumin to creatinine ratio; Creatinine clearance rate; Glomerulosclerosis" @default.
- W3028688614 created "2020-06-05" @default.
- W3028688614 creator A5005565910 @default.
- W3028688614 creator A5008801443 @default.
- W3028688614 creator A5022109876 @default.
- W3028688614 creator A5051550448 @default.
- W3028688614 creator A5067522777 @default.
- W3028688614 creator A5068427892 @default.
- W3028688614 date "2016-10-08" @default.
- W3028688614 modified "2023-09-28" @default.
- W3028688614 title "Effect of apoptosis signal regulating kinase 1 inhibitor on glomerulosclerosis in 5/6 nephrectomy rats" @default.
- W3028688614 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2016.10.038" @default.
- W3028688614 hasPublicationYear "2016" @default.
- W3028688614 type Work @default.
- W3028688614 sameAs 3028688614 @default.
- W3028688614 citedByCount "0" @default.
- W3028688614 crossrefType "journal-article" @default.
- W3028688614 hasAuthorship W3028688614A5005565910 @default.
- W3028688614 hasAuthorship W3028688614A5008801443 @default.
- W3028688614 hasAuthorship W3028688614A5022109876 @default.
- W3028688614 hasAuthorship W3028688614A5051550448 @default.
- W3028688614 hasAuthorship W3028688614A5067522777 @default.
- W3028688614 hasAuthorship W3028688614A5068427892 @default.
- W3028688614 hasConcept C126322002 @default.
- W3028688614 hasConcept C126894567 @default.
- W3028688614 hasConcept C134018914 @default.
- W3028688614 hasConcept C159641895 @default.
- W3028688614 hasConcept C27016395 @default.
- W3028688614 hasConcept C2777390665 @default.
- W3028688614 hasConcept C2779561371 @default.
- W3028688614 hasConcept C2779611605 @default.
- W3028688614 hasConcept C2780091579 @default.
- W3028688614 hasConcept C2780227381 @default.
- W3028688614 hasConcept C2780306776 @default.
- W3028688614 hasConcept C71924100 @default.
- W3028688614 hasConcept C84393581 @default.
- W3028688614 hasConceptScore W3028688614C126322002 @default.
- W3028688614 hasConceptScore W3028688614C126894567 @default.
- W3028688614 hasConceptScore W3028688614C134018914 @default.
- W3028688614 hasConceptScore W3028688614C159641895 @default.
- W3028688614 hasConceptScore W3028688614C27016395 @default.
- W3028688614 hasConceptScore W3028688614C2777390665 @default.
- W3028688614 hasConceptScore W3028688614C2779561371 @default.
- W3028688614 hasConceptScore W3028688614C2779611605 @default.
- W3028688614 hasConceptScore W3028688614C2780091579 @default.
- W3028688614 hasConceptScore W3028688614C2780227381 @default.
- W3028688614 hasConceptScore W3028688614C2780306776 @default.
- W3028688614 hasConceptScore W3028688614C71924100 @default.
- W3028688614 hasConceptScore W3028688614C84393581 @default.
- W3028688614 hasIssue "10" @default.
- W3028688614 hasLocation W30286886141 @default.
- W3028688614 hasOpenAccess W3028688614 @default.
- W3028688614 hasPrimaryLocation W30286886141 @default.
- W3028688614 hasRelatedWork W1982039761 @default.
- W3028688614 hasRelatedWork W2054700242 @default.
- W3028688614 hasRelatedWork W2079246004 @default.
- W3028688614 hasRelatedWork W2303797738 @default.
- W3028688614 hasRelatedWork W2357339225 @default.
- W3028688614 hasRelatedWork W2362458493 @default.
- W3028688614 hasRelatedWork W2365900760 @default.
- W3028688614 hasRelatedWork W2373713805 @default.
- W3028688614 hasRelatedWork W2379649579 @default.
- W3028688614 hasRelatedWork W2379948505 @default.
- W3028688614 hasRelatedWork W2389943664 @default.
- W3028688614 hasRelatedWork W2390097322 @default.
- W3028688614 hasRelatedWork W2390758051 @default.
- W3028688614 hasRelatedWork W2399946506 @default.
- W3028688614 hasRelatedWork W2411473669 @default.
- W3028688614 hasRelatedWork W2473620522 @default.
- W3028688614 hasRelatedWork W2979278521 @default.
- W3028688614 hasRelatedWork W3031309474 @default.
- W3028688614 hasRelatedWork W3032256372 @default.
- W3028688614 hasRelatedWork W998242857 @default.
- W3028688614 hasVolume "33" @default.
- W3028688614 isParatext "false" @default.
- W3028688614 isRetracted "false" @default.
- W3028688614 magId "3028688614" @default.
- W3028688614 workType "article" @default.