Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028696546> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3028696546 endingPage "363" @default.
- W3028696546 startingPage "359" @default.
- W3028696546 abstract "Objective To observe the dynamic changes of growth arrest and DNA damage inducible gene 153 (GADD 153) and caspase-12 expressions in the brain of rats after ischemia-reperfusion,and explore the role of endoplasmic reticulum stress in ischemia-reperfusion brain injury.Methods Forty-two rats were randomly divided into control group (n=3),sham-operated group (n=3) and ischemia-reperfusion group (n=36); the rats of ischemia-reperfusion group were randomly sub-divided into groups of 2 h occlusion and 6,12,24,72 h reperfusion (n=9).Modified Longa intraluminal thread method was adopted to establish the middle cerebral artery occlusion-reperfusion models.Expression changes of GADD 153 and caspase-12 at different time points were detected by immunohistochemistry,double-label immunofluorescence and Western blotting.Results Immunohistochemistry and Western blotting showed that the expressions of GADD153 and caspase-12 in the control group and sham-operated group was negative; the GADD 153 expression increased in group of 6 h reperfusion,and that in group of 72 h reperfusion was significantly higher than that in group of 6 h reperfusion (P＜0.05);the caspase-12 expression increased in group of 6 h reperfusion,enjoyed the highest level in group of 24 h reperfusion which had significant difference as compared with that in group of 6 h reperfusion (P＜0.05),and still maintained at a high level in group of 72 h repefusion.Double immunofluorescence staining showed that GADD153 and caspase-12 double-positive cells could be seen in group of 6 h reperfusion;that at groups of 12 and 24 h reperfusion significantly increased as compared with that in group of 6 h reperfusion (P＜0.05); the number of caspase-12 single-positive cells reduced,that of GADD153 single-positive cells was still large,and the number of double-positive cells reduced.Conclusion The expression changes of GADD153 and caspase-12 are time dependent,indicating that endoplasmic reticulum stress involve in the pathological process of ischemia-reperfusion brain injury.Key words: Cerebral ischemia-reperfusion; Growth arrest and DNA damage inducible gene 153; Caspase 12; Endoplasmic reticulum stress" @default.
- W3028696546 created "2020-06-05" @default.
- W3028696546 creator A5010139762 @default.
- W3028696546 creator A5029500794 @default.
- W3028696546 creator A5050843346 @default.
- W3028696546 creator A5073940048 @default.
- W3028696546 date "2013-04-15" @default.
- W3028696546 modified "2023-09-24" @default.
- W3028696546 title "Role of endoplasmic reticulum stress in rats after ischemia-reperfusion brain injury" @default.
- W3028696546 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2013.04.008" @default.
- W3028696546 hasPublicationYear "2013" @default.
- W3028696546 type Work @default.
- W3028696546 sameAs 3028696546 @default.
- W3028696546 citedByCount "0" @default.
- W3028696546 crossrefType "journal-article" @default.
- W3028696546 hasAuthorship W3028696546A5010139762 @default.
- W3028696546 hasAuthorship W3028696546A5029500794 @default.
- W3028696546 hasAuthorship W3028696546A5050843346 @default.
- W3028696546 hasAuthorship W3028696546A5073940048 @default.
- W3028696546 hasConcept C104317684 @default.
- W3028696546 hasConcept C126322002 @default.
- W3028696546 hasConcept C134018914 @default.
- W3028696546 hasConcept C158617107 @default.
- W3028696546 hasConcept C159654299 @default.
- W3028696546 hasConcept C16685009 @default.
- W3028696546 hasConcept C203014093 @default.
- W3028696546 hasConcept C204232928 @default.
- W3028696546 hasConcept C2776268601 @default.
- W3028696546 hasConcept C2778236600 @default.
- W3028696546 hasConcept C2780114680 @default.
- W3028696546 hasConcept C541997718 @default.
- W3028696546 hasConcept C55493867 @default.
- W3028696546 hasConcept C71924100 @default.
- W3028696546 hasConcept C85265743 @default.
- W3028696546 hasConcept C86803240 @default.
- W3028696546 hasConceptScore W3028696546C104317684 @default.
- W3028696546 hasConceptScore W3028696546C126322002 @default.
- W3028696546 hasConceptScore W3028696546C134018914 @default.
- W3028696546 hasConceptScore W3028696546C158617107 @default.
- W3028696546 hasConceptScore W3028696546C159654299 @default.
- W3028696546 hasConceptScore W3028696546C16685009 @default.
- W3028696546 hasConceptScore W3028696546C203014093 @default.
- W3028696546 hasConceptScore W3028696546C204232928 @default.
- W3028696546 hasConceptScore W3028696546C2776268601 @default.
- W3028696546 hasConceptScore W3028696546C2778236600 @default.
- W3028696546 hasConceptScore W3028696546C2780114680 @default.
- W3028696546 hasConceptScore W3028696546C541997718 @default.
- W3028696546 hasConceptScore W3028696546C55493867 @default.
- W3028696546 hasConceptScore W3028696546C71924100 @default.
- W3028696546 hasConceptScore W3028696546C85265743 @default.
- W3028696546 hasConceptScore W3028696546C86803240 @default.
- W3028696546 hasIssue "04" @default.
- W3028696546 hasLocation W30286965461 @default.
- W3028696546 hasOpenAccess W3028696546 @default.
- W3028696546 hasPrimaryLocation W30286965461 @default.
- W3028696546 hasRelatedWork W2347271419 @default.
- W3028696546 hasRelatedWork W2351329744 @default.
- W3028696546 hasRelatedWork W2351348253 @default.
- W3028696546 hasRelatedWork W2354320560 @default.
- W3028696546 hasRelatedWork W2357410234 @default.
- W3028696546 hasRelatedWork W2359721582 @default.
- W3028696546 hasRelatedWork W2361337103 @default.
- W3028696546 hasRelatedWork W2363855928 @default.
- W3028696546 hasRelatedWork W2373052054 @default.
- W3028696546 hasRelatedWork W2377852884 @default.
- W3028696546 hasRelatedWork W2378230016 @default.
- W3028696546 hasRelatedWork W2379759076 @default.
- W3028696546 hasRelatedWork W2386498202 @default.
- W3028696546 hasRelatedWork W2387558794 @default.
- W3028696546 hasRelatedWork W2391429985 @default.
- W3028696546 hasRelatedWork W2392448264 @default.
- W3028696546 hasRelatedWork W2588336745 @default.
- W3028696546 hasRelatedWork W3029360646 @default.
- W3028696546 hasRelatedWork W3029598462 @default.
- W3028696546 hasRelatedWork W3031619189 @default.
- W3028696546 hasVolume "12" @default.
- W3028696546 isParatext "false" @default.
- W3028696546 isRetracted "false" @default.
- W3028696546 magId "3028696546" @default.
- W3028696546 workType "article" @default.