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- W3028697218 abstract "ObjectiveTo investigate the peripheral immune status of patient suffered from Good′s syndrome (GS).MethodsCD4+ T cells, CD8+ T cells and γδT cells and corresponding cellular cytokines of IFN-γ and IL-17A were measured by flow cytometry.Meanwhile, we detected the level of CD4+ CD25+ Foxp3+ , CD4+ CD25+ CTLA-4+ , CD8+ CD28-, CD8+ Foxp3+ Tregs in peripheral blood of GS patients and health controls (n=10) through FACS.ResultsCompared with health controls, GS patient presented a significantly trend of lower CD4+ T cells, relatively higher CD8+ T cells, which led to inversed ratio of CD4/CD8.There was no difference in the level of γδT cells between GS patient and HC.However, the subgroup of Vδ2T cells were in lower level, with relatively higher proportion of Vδ1T cells in GS patient.Moreover, the CD8+ T cells secreted more IFN-γ, and with lower level of IFN-γ derived from γδT cells in GS patient; In other respect, GS patient showed a relatively higher proportion of Th17.Compared with health controls, higher percentages of various kinds of Tregs were infiltrated in peripheral blood with GS patient.ConclusionsThere is a phenomenon of down-regulation of peripheral immunity in GS patient including higher density of peripheral Tregs, which can provide a clue for immunotherapy of GS in future.Key words: Good′s syndrome; Cellular cytokine; Regulatory T cell" @default.
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- W3028697218 date "2017-12-05" @default.
- W3028697218 modified "2023-09-24" @default.
- W3028697218 title "One case report of Good′s syndrome with research of immune status" @default.
- W3028697218 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2017.23.010" @default.
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