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- W3028700606 abstract "ObjectiveTo explore the association of the expression levels ofβ-tubulinⅢ(TuBB3) in esophageal cancer with the neoadjuvant chemotherapy efficacy of paelitaxel.MethodsThe expression levels of TuBB3 were detected by immnohistochemistry. The association of the TuBB3 expression with the neoadjuvant chemotherapy efficacy of paelitaxel, the radical resection rate of tumor, the postoperative pathological staging and one-year survival rate was analyzed.ResultsThe response rate of chemotherapy in the group with lower TuBB3 expression was higher than that with higher expression(68. 4% and 41. 2%).The group with lower TuBB3 also had higher radical resection rate of tumor(94. 6% and 78. 7%), lower postoperative pathological staging and higher one-year survival rate(89. 2% and 68. 8%)than that with higher expression(P< 0. 05).ConclusionTuBB3 can be a predictor for the efficacy of paelitaxel-based chemotherapy in the neoadjuvant treatment of esophageal cancer.Esophageal cancer patients with lowerl TuBB3 expression has higher radical resection rate of tumor, and more survival benefit postoperatively when treatment with paelitaxel.Key words: Esophageal carcinoma; Paelitaxel; β-tubulinⅢ; Chemotherapy" @default.
- W3028700606 created "2020-06-05" @default.
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- W3028700606 date "2015-06-08" @default.
- W3028700606 modified "2023-09-23" @default.
- W3028700606 title "Association of expression ofβ-tubulinIIIwith neoadjuvant chemotherapy efficacy of paelitaxel in advanced esophageal carcinoma" @default.
- W3028700606 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2015.06.079" @default.
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